基于自动手表工作原理的无电池心脏起搏器

A new batteryless cardiac pacemaker based on an automatic wristwatch and powered by heart motion was presented at ESC Congress 2014 today by Adrian Zurbuchen from Switzerland. The prototype device does not require battery replacement¹. Mr Zurbuchen, a PhD candidate in the Cardiovascular Engineering Group at ARTORG, University of Bern, Switzerland, said: "Batteries are a limiting factor in today's medical implants². Once they reach a critically low energy level, physicians see themselves forced to replace a correctly functioning medical device in a surgical³ intervention⁴. This is an unpleasant scenario⁵ which increases costs and the risk of complications for patients."

 

At ESC Congress, Mr Zurbuchen presents a way to power a cardiac pacemaker with an alternative energy source -- the heart motion.

 

Four years ago Professor Rolf Vogel, a cardiologist and engineer at the University of Bern, had the idea of using an automatic wristwatch mechanism⁶ to harvest the energy of heart motion. Mr Zurbuchen said: "The heart seems to be a very promising⁷ energy source because its contractions⁸ are repetitive and present for 24 hours a day, 7 days a week. Furthermore the automatic clockwork, invented in the year 1777, has a good reputation as a reliable technology to scavenge（打扫，清除） energy from motion."

 

The researchers' first prototype is based on a commercially available automatic wristwatch. All unnecessary parts were removed to reduce weight and size. In addition, they developed a custom-made housing with eyelets（孔眼） that allows suturing（缝合） the device directly onto the myocardium（心肌）.

 

The prototype works the same way it would on a person's wrist. When it is exposed to an external acceleration⁹, the eccentric mass of the clockwork starts rotating. This rotation¹⁰ progressively winds a mechanical spring. After the spring is fully¹¹ charged it unwinds and thereby¹² spins an electrical micro-generator.

 

To test the prototype, the researchers developed an electronic circuit to transform and store the signal into a small buffer¹³ capacity. They then connected the system to a custom-made cardiac pacemaker (photo 2). The system worked in three steps. First, the harvesting prototype acquired energy from the heart. Second, the energy was temporarily stored in the buffer capacity. And finally, the buffered¹⁴ energy was used by the pacemaker to apply minute stimuli¹⁵ to the heart.

 

The researchers successfully tested the system in in vivo experiments with domestic pigs. The newly developed system allowed them for the first time to perform batteryless overdrive-pacing at 130 beats per minute.

 

Mr Zurbuchen said: "We have shown that it is possible to pace the heart using the power of its own motion. The next step in our prototype is to integrate both the electronic circuit for energy storage and the custom-made pacemaker directly into the harvesting device. This will eliminate the need for leads."

 

He concluded: "Our new pacemaker tackles the two major disadvantages of today's pacemakers. First, pacemaker leads are prone¹⁶ to fracture and can pose an imminent¹⁷ threat to the patient. And second, the lifetime of a pacemaker battery is limited. Our energy harvesting system is located directly on the heart and has the potential to avoid both disadvantages by providing the world with a batteryless and leadless pacemaker."

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