研究人员使干细胞转变成血管内皮细胞

时间：2010-01-22 01:16:14

（单词翻译:单击）

New York Stem Cell干细胞 Foundation (NYSCF)-Druckenmiller Fellow, Daylon James, PhD, of Weill Cornell Medial College, is lead author on a study defining conditions for generating a plentiful1 supply of endothelial内皮的 (vessel lining) cells that are suitable for therapeutic治疗的 use. Dr. James and his colleagues created a human embryonic胚胎的 stem cell (hESC) "reporter" line that can be used to measure endothelial cell production and activity. The study, Expansion and maintenance of human embryonic3 stem cell–derived endothelial cells by TGFβ inhibition is Id1 dependent, was published in the online edition of Nature Biotechnology on January 17th, 2010, and will also appear in the journal's print edition. In addition to Dr. James, whose work is funded by NYSCF, contributors to the study also included NYSCF-Druckenmiller Fellows, Drs. Gabsang Lee and Marco Seandel.

Using the reporter line, Dr. James and his colleagues were able to monitor the emergence4出现，浮现 of endothelial cells in live cultures, and screen for small bioactive生物活性的 molecules5 that increased their yield. By this method, they were able to indentify a compound that robustly6 increased the amount of endothelial cells produced. This work establishes a standard methodology for generating functional7 endothelial cells from hESCs using conditions that are suited to clinical application. These cells can now be routinely and economically produced on scales that make pre-clinical assessment8 of their efficacy practical in large animal models of vascular血管的 disease.

"We are very proud of Dr. James. These findings bring us closer to having functional endothelial cells available for studying vascular9 disease," says Susan L. Solomon, NYSCF's founder10 and CEO.

As advancements11 in induced pluripotent多能的 stem (iPS) cell technology continue, hESC research like that of Dr. James is essential for the field of stem cell research. Embryonic stem cells are still the gold standard for monitoring pluripotency and differentiation12 capabilities13.

"It is research like this that brings us closer to cures for the major diseases of our time," said Dr. Kevin Eggan, Chief Scientific Officer of NYSCF. "Daylon is one of the premier第一的，最初的 young scientists in the field of stem cell research and we are excited to have him in our fellowship program."


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1 plentiful r2izH     
adj.富裕的，丰富的
参考例句：
  • Their family has a plentiful harvest this year.他们家今年又丰收了。
  • Rainfall is plentiful in the area.这个地区雨量充足。
2 therapeutic sI8zL     
adj.治疗的，起治疗作用的；对身心健康有益的
参考例句：
  • Therapeutic measures were selected to fit the patient.选择治疗措施以适应病人的需要。
  • When I was sad,music had a therapeutic effect.我悲伤的时候，音乐有治疗效力。
3 embryonic 58EyK     
adj.胚胎的
参考例句：
  • It is still in an embryonic stage.它还处于萌芽阶段。
  • The plan,as yet,only exists in embryonic form.这个计划迄今为止还只是在酝酿之中。
4 emergence 5p3xr     
n.浮现，显现，出现，（植物）突出体
参考例句：
  • The last decade saw the emergence of a dynamic economy.最近10年见证了经济增长的姿态。
  • Language emerges and develops with the emergence and development of society.语言是随着社会的产生而产生，随着社会的发展而发展的。
5 molecules 187c25e49d45ad10b2f266c1fa7a8d49     
分子( molecule的名词复数 )
参考例句：
  • The structure of molecules can be seen under an electron microscope. 分子的结构可在电子显微镜下观察到。
  • Inside the reactor the large molecules are cracked into smaller molecules. 在反应堆里，大分子裂变为小分子。
6 robustly 507ac3bec7e7c48e608da00e709f9006     
adv.要用体力地，粗鲁地
参考例句：
  • These three hormones also robustly stimulated thymidine incorporation and inhibited drug-induced apoptosis. 并且这三种激素有利于胸（腺嘧啶脱氧核）苷掺入和抑制药物诱导的细胞凋亡。 来自互联网
  • The economy is still growing robustly, but inflation, It'seems, is back. 经济依然强劲增长，但是通胀似乎有所抬头。 来自互联网
7 functional 5hMxa     
adj.为实用而设计的，具备功能的，起作用的
参考例句：
  • The telephone was out of order,but is functional now.电话刚才坏了，但现在可以用了。
  • The furniture is not fancy,just functional.这些家具不是摆着好看的，只是为了实用。
8 assessment vO7yu     
n.评价；评估；对财产的估价，被估定的金额
参考例句：
  • This is a very perceptive assessment of the situation.这是一个对该情况的极富洞察力的评价。
  • What is your assessment of the situation?你对时局的看法如何？
9 vascular cidw6     
adj.血管的，脉管的
参考例句：
  • The mechanism of this anomalous vascular response is unknown.此种不规则的血管反应的机制尚不清楚。
  • The vascular changes interfere with diffusion of nutrients from plasma into adjacent perivascular tissue and cells.这些血管变化干扰了营养物质从血浆中向血管周围邻接的组织和细胞扩散。
10 Founder wigxF     
n.创始者，缔造者
参考例句：
  • He was extolled as the founder of their Florentine school.他被称颂为佛罗伦萨画派的鼻祖。
  • According to the old tradition,Romulus was the founder of Rome.按照古老的传说，罗穆卢斯是古罗马的建国者。
11 advancements d9d88b0aa041a51f56ca9b4113bf311c     
n.（级别的）晋升( advancement的名词复数 )；前进；进展；促进
参考例句：
  • Today, the pace of life is increasing with technological advancements. 当今， 随着科技进步，生活节奏不断增快。 来自《现代汉英综合大词典》
  • Great advancements in drought prediction have been made in recent years. 近年来，人们对干旱灾害的预报研究取得了长足的进步。 来自互联网
12 differentiation wuozfs     
n.区别，区分
参考例句：
  • There can be no differentiation without contrast. 有比较才有差别。
  • The operation that is the inverse of differentiation is called integration. 与微分相反的运算叫做积分。
13 capabilities f7b11037f2050959293aafb493b7653c     
n.能力( capability的名词复数 )；可能；容量；[复数]潜在能力
参考例句：
  • He was somewhat pompous and had a high opinion of his own capabilities. 他有点自大，自视甚高。 来自辞典例句
  • Some programmers use tabs to break complex product capabilities into smaller chunks. 一些程序员认为，标签可以将复杂的功能分为每个窗格一组简单的功能。 来自About Face 3交互设计精髓
14 premier R19z3     
adj.首要的；n.总理，首相
参考例句：
  • The Irish Premier is paying an official visit to Britain.爱尔兰总理正在对英国进行正式访问。
  • He requested that the premier grant him an internview.他要求那位总理接见他一次。

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