威尔士科学家克隆出一种人体病毒

时间：2010-09-14 02:46:58

（单词翻译:单击）

A team of Welsh scientists have successfully cloned a human virus offering new hope for the treatment of potentially life-threatening diseases. Human cytomegalovirus（巨细胞病毒） (HCMV) is a major infectious cause of congenital malformations（先天畸形） worldwide. The virus is also known to cause life-threatening disease in transplant patients and people with HIV/AIDS.

The development of new treatments has been hampered1（阻碍，限制） as scientists have been unable to stably replicate2 HCMV outside the human body.

Dr Richard Stanton from Cardiff University's School of Medicine who led the joint3 research, said: "HCMV has by far the largest genome of all viruses affecting humans - consequently it was technically4 difficult to clone in an intact（完整的） form in the laboratory.

"Cloning a copy of the virus from a strain isolated5 by Cardiff Public Health Laboratories has enabled us to identify the genes6 causing the instability of the virus outside the body.

"Following the identification of these genes, we have successfully developed cells in which we can grow virus that corresponds to that which exists in the human body."

Cloning the virus for the first time will help virologists（滤过性病原体学者） develop antivirals and vaccines8 against the virus that causes clinical disease.

Following the study, the clone has already been distributed to research laboratories worldwide, and is being tested by the World Health Organisation9 (WHO) as part of a study to develop an international diagnostic standard with which to compare clinical isolates10.

The genome sequence of the Cardiff virus has also been designated the international reference for HCMV in the National Centre for Biotechnology Information (NCBI) - an international database that provides reference standards for biomedical（生物医学的） and genomic information.

Dr Stanton added: "HCMV has been designated as a highest priority vaccine7 target by the US Institute of Medicine. When developing vaccines, anti-viral agents and improving understanding of disease, it is crucial to work with a virus that accurately11 represents the virus present in patients.

"For the first time our work has enabled us to create an exact copy of the virus outside of the body offering a vital step forward in the development of new treatments."

The study, published in the The Journal of Clinical Investigationand funded by the Wellcome Trust and the Medical Research Council, was a joint collaboration12 between Cardiff University's Infection, Immunity13 and Inflammation Interdisciplinary（各学科间的） Research Group and Drs Davison and Dargan at the Centre for Virus Research at the University of Glasgow.

The virus, named Merlin, was isolated from a clinical sample identified by the Diagnostic Unit, Public Health Wales.


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1 hampered 3c5fb339e8465f0b89285ad0a790a834     
妨碍，束缚，限制( hamper的过去式和过去分词 )
参考例句：
  • The search was hampered by appalling weather conditions. 恶劣的天气妨碍了搜寻工作。
  • So thought every harassed, hampered, respectable boy in St. Petersburg. 圣彼德堡镇的那些受折磨、受拘束的体面孩子们个个都是这么想的。
2 replicate PVAxN     
v.折叠，复制，模写；n.同样的样品；adj.转折的
参考例句：
  • The DNA of chromatin must replicate before cell division.染色质DNA在细胞分裂之前必须复制。
  • It is also easy to replicate,as the next subsection explains.就像下一个小节详细说明的那样，它还可以被轻易的复制。
3 joint m3lx4     
adj.联合的，共同的；n.关节，接合处；v.连接，贴合
参考例句：
  • I had a bad fall,which put my shoulder out of joint.我重重地摔了一跤，肩膀脫臼了。
  • We wrote a letter in joint names.我们联名写了封信。
4 technically wqYwV     
adv.专门地，技术上地
参考例句：
  • Technically it is the most advanced equipment ever.从技术上说，这是最先进的设备。
  • The tomato is technically a fruit,although it is eaten as a vegetable.严格地说，西红柿是一种水果，尽管它是当作蔬菜吃的。
5 isolated bqmzTd     
adj.与世隔绝的
参考例句：
  • His bad behaviour was just an isolated incident. 他的不良行为只是个别事件。
  • Patients with the disease should be isolated. 这种病的患者应予以隔离。
6 genes 01914f8eac35d7e14afa065217edd8c0     
n.基因( gene的名词复数 )
参考例句：
  • You have good genes from your parents, so you should live a long time. 你从父母那儿获得优良的基因，所以能够活得很长。 来自《简明英汉词典》
  • Differences will help to reveal the functions of the genes. 它们间的差异将会帮助我们揭开基因多种功能。 来自英汉非文学 - 生命科学 - 生物技术的世纪
7 vaccine Ki1wv     
n.牛痘苗，疫苗；adj.牛痘的，疫苗的
参考例句：
  • The polio vaccine has saved millions of lives.脊髓灰质炎疫苗挽救了数以百万计的生命。
  • She takes a vaccine against influenza every fall.她每年秋季接种流感疫苗。
8 vaccines c9bb57973a82c1e95c7cd0f4988a1ded     
疫苗，痘苗( vaccine的名词复数 )
参考例句：
  • His team are at the forefront of scientific research into vaccines. 他的小组处于疫苗科研的最前沿。
  • The vaccines were kept cool in refrigerators. 疫苗放在冰箱中冷藏。
9 organisation organisation     
n.组织，安排，团体，有机休
参考例句：
  • The method of his organisation work is worth commending.他的组织工作的方法值得称道。
  • His application for membership of the organisation was rejected.他想要加入该组织的申请遭到了拒绝。
10 isolates 338356f90b44ba66febab4a4c173b0f7     
v.使隔离( isolate的第三人称单数 )；将…剔出（以便看清和单独处理）；使（某物质、细胞等）分离；使离析
参考例句：
  • The transformer isolates the transistors with regard to d-c bias voltage. 变压器可在两个晶体管之间隔离直流偏压。 来自辞典例句
  • In regions with certain isolates of TRV, spraining is more prominent. 在具有TRV某些分离物的地区，坏死是比较显著的。 来自辞典例句
11 accurately oJHyf     
adv.准确地，精确地
参考例句：
  • It is hard to hit the ball accurately.准确地击中球很难。
  • Now scientists can forecast the weather accurately.现在科学家们能准确地预报天气。
12 collaboration bW7yD     
n.合作，协作；勾结
参考例句：
  • The two companies are working in close collaboration each other.这两家公司密切合作。
  • He was shot for collaboration with the enemy.他因通敌而被枪毙了。
13 immunity dygyQ     
n.优惠；免除；豁免，豁免权
参考例句：
  • The law gives public schools immunity from taxation.法律免除公立学校的纳税义务。
  • He claims diplomatic immunity to avoid being arrested.他要求外交豁免以便避免被捕。

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