科学家发现生物膜感染机制

What: Scientists from the National Institutes of Health have discovered how catheter（导管） -related bacterial¹ infection develops and disseminates³ to become a potentially life-threatening condition. The study, which included research on Staphylococcus epidermidis（表皮葡萄球菌） in mice implanted with catheters, could have important implications for understanding many types of bacterial biofilm（生物膜，菌膜） infections, including those caused by methicillin（甲氧西林） -resistant S. aureus (MRSA). Biofilms are clusters of microbes that almost always are found with healthcare-associated infections (HAIs) involving medical devices such as catheters, pacemakers and prosthetics（修复学） . Most often biofilms that develop on such devices consist of Staph bacteria. Because biofilms inherently（内在地，固有地） resist antibiotics⁴ and immune defenses, treating patients with biofilm-associated infections can be difficult and expensive. An estimated two million HAIs, most of which are associated with biofilms, occur in the United States annually⁵, accounting⁶ for about 100,000 deaths.

Although biofilm-related infections result in significant numbers of deaths, scientists still have a limited understanding of how biofilms develop at a molecular⁷ level. But now scientists from NIH's National Institute of Allergy⁸ and Infectious Diseases (NIAID) have identified a specific S. epidermidis protein, called phenol-soluble modulin beta (PSM-beta), that biofilms use for multiple purposes: to grow, to detach from（分离，拆卸） an implanted medical device, and to disseminate²（传播） infection. Antibodies against PSM-beta slowed bacterial spread within the study mice, suggesting that interfering⁹ with biofilm development could provide a way to stop the spread of biofilm-associated infection.

Similar proteins also are found in S. aureus, and the research group now plans to study their role in biofilms of MRSA and other bacteria.