酒精能提高记忆力

Drinking alcohol primes certain areas of our brain to learn and remember better, says a new study from the Waggoner Center for Alcohol and Addiction¹ Research at The University of Texas at Austin. The common view that drinking is bad for learning and memory isn't wrong, says neurobiologist Hitoshi Morikawa, but it highlights only one side of what ethanol（乙醇） consumption does to the brain.

"Usually, when we talk about learning and memory, we're talking about conscious memory," says Morikawa, whose results were published last month in The Journal of Neuroscience. "Alcohol diminishes our ability to hold on to pieces of information like your colleague's name, or the definition of a word, or where you parked your car this morning. But our subconscious²（潜意识） is learning and remembering too, and alcohol may actually increase our capacity to learn, or 'conditionability,' at that level."

Morikawa's study, which found that repeated ethanol exposure enhances synaptic plasticity（突触可塑性） in a key area in the brain, is further evidence toward an emerging consensus³ in the neuroscience community that drug and alcohol addiction is fundamentally a learning and memory disorder⁴.

When we drink alcohol (or shoot up heroin⁵, or snort cocaine⁶, or take methamphetamines), our subconscious is learning to consume more. But it doesn't stop there. We become more receptive to forming subsconscious memories and habits with respect to food, music, even people and social situations.

In an important sense, says Morikawa, alcoholics⁷ aren't addicted⁸ to the experience of pleasure or relief they get from drinking alcohol. They're addicted to the constellation⁹ of environmental, behavioral and physiological¹⁰ cues that are reinforced when alcohol triggers the release of dopamine（多巴胺） in the brain.

"People commonly think of dopamine as a happy transmitter, or a pleasure transmitter, but more accurately¹¹ it's a learning transmitter," says Morikawa. "It strengthens those synapses¹² that are active when dopamine is released."

Alcohol, in this model, is the enabler. It hijacks¹³ the dopaminergic system, and it tells our brain that what we're doing at that moment is rewarding (and thus worth repeating).

Among the things we learn is that drinking alcohol is rewarding. We also learn that going to the bar, chatting with friends, eating certain foods and listening to certain kinds of music are rewarding. The more often we do these things while drinking, and the more dopamine that gets released, the more "potentiated" the various synapses become and the more we crave¹⁴ the set of experiences and associations that orbit around the alcohol use.

Morikawa's long-term hope is that by understanding the neurobiological underpinnings（基础，支柱） of addiction better, he can develop anti-addiction drugs that would weaken, rather than strengthen, the key synapses. And if he can do that, he would be able to erase¹⁵ the subconscious memory of addiction.

"We're talking about de-wiring things," says Morikawa. "It's kind of scary because it has the potential to be a mind controlling substance. Our goal, though, is to reverse the mind controlling aspects of addictive¹⁶ drugs."