自闭症能改变大脑的分子结构

For decades, autism（自闭症） researchers have faced a baffling riddle¹: how to unravel² a disorder³ that leaves no known physical trace as it develops in the brain. Now a UCLA study is the first to reveal how the disorder makes its mark at the molecular⁴ level, resulting in an autistic brain that differs dramatically in structure from a healthy one. Published May 25 in the advance online edition of Nature, the findings provide new insight into how genes⁶ and proteins go awry⁷ in autism to alter the mind.

The discovery also identifies a new line of attack for researchers, who currently face a vast array of potential fronts for tackling the neurological disease and identifying its diverse causes.

"If you randomly⁸ pick 20 people with autism, the cause of each person's disease will be unique," said principal investigator⁹ Dr. Daniel Geschwind, the Gordon and Virginia MacDonald Distinguished¹⁰ Chair in Human Genetics and a professor of neurology and psychiatry¹¹ at the David Geffen School of Medicine at UCLA. "Yet when we examined how genes and proteins interact in autistic people's brains, we saw well-defined shared patterns. This common thread could hold the key to pinpointing¹² the disorder's origins."

The research team, led by Geschwind, included scientists from the University of Toronto and King's College London. They compared brain tissue samples obtained after death from 19 autism patients and 17 healthy volunteers. After profiling three brain areas previously¹³ linked to autism, the group zeroed in on the cerebral¹⁴ cortex（大脑皮层） , the most evolved part of the human brain.

The researchers focused on gene⁵ expression — how a gene's DNA¹⁵ sequence is copied into RNA, which directs the synthesis of cellular¹⁶ molecules¹⁷ called proteins. Each protein is assigned a specific task by the gene to perform in the cell.

By measuring gene-expression levels in the cerebral cortex, the team uncovered consistent differences in how genes in autistic and healthy brains encode information.