科学家发现气管修复干细胞

Researchers at UCLA have identified a new stem cell that participates in the repair of the large airways² of the lungs, which play a vital role in protecting the body from infectious agents and toxins³ in the environment. The airways protect the body by producing and clearing mucus（粘液） from the airways. The mucus is largely produced by specialized⁴ mucus glands⁶ in the airway¹ and the mechanisms⁷ of normal and excessive mucus production are not well understood. However, this newly discovered lung stem cell for the mucus glands will likely yield new insights into this critical process.

The study, by scientists with the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA, represents the first time anyone has found the cell of origin for the many types of cells that make up the mucus glands and that can also repair the surface epithelium（上皮细胞） . The finding, the study states, is of "major importance to the field of lung regeneration."

"We're very excited that we found this population of cells because it will allow us to study mechanisms of diseases of the upper airway," said Dr. Brigitte Gomperts, an assistant professor of pediatrics（小儿科） and hematology/oncology and senior author of the study. "For example, there currently are no treatments for excess mucus production, which we see in cystic fibrosis, asthma⁸ and chronic⁹ obstructive pulmonary disease (COPD). But if we can understand the mechanisms of how these stem cells repair the mucus glands, then we may be able to find a way to put the brakes on the system and prevent mucus over production."

The study appears in the June 27, 2011 issue of the peer-reviewed journal Stem Cells.

Ahmed Hegab, a postdoctoral scholar in Gomperts lab and first author on the study, named the newly discovered cells sub-mucosal gland⁵ duct stem cells, because they are found in the ducts where the mucus is first secreted¹⁰. Hegab and Gomperts had been looking for the lung stem cells for years, and created a model of repair of the airways in order to identify the location of the stem cells.

Once Gomperts and her team proved that the lung stem cells existed and found where they "lived," they set out to isolate¹¹ them and confirm that they could self-renew, or grow more of themselves, and differentiate¹², turn into the cells that make up the mucus glands and surface epithelium. They created model systems in which these isolated¹³ stem cells did, in fact, make mucus glands with all the types of cells required to make mucus and repair the surface barrier of the large airways.

"Our ability to identify the stem cells and their regenerative ability has implications for the possible identification of novel therapeutic¹⁴ targets for airway diseases and potential cell-based therapies in the future," the study states.

The stem cells also may play a role in tumor¹⁵ initiation¹⁶ in lung cancer when the repair goes awry¹⁷, although further study is needed to confirm this, said Gomperts, who is also a member of UCLA's Jonsson Comprehensive Cancer Center.