骨髓细胞能抑制肿瘤生长

Bone marrow¹-derived cells (BMDCs) participate in the growth and spread of tumors of the breast, brain, lung, and stomach. To examine the role of BMDCs, researchers developed a mouse model that could be used to track the migration³ of these cells while tumors formed and expanded. Their results, published in the November issue of The American Journal of Pathology, strongly suggest that more effective cancer treatments may be developed by exploiting the mechanism⁴ by which bone marrow cells migrate to tumors and retard⁵ their proliferation（扩散） . "Our results provide an excellent in vivo（在活体内） experimental model where the temporal dynamics⁶ of tumor²-infiltrating BMDCs may be monitored in an immunocompetent（免疫活性的） host and novel therapies targeting BMDCs for the inhibition of tumor progression may be investigated," commented lead investigator⁷ Wafik S. El-Deiry, MD, PhD, Professor and Chief, Hematology/Oncology Division at the Penn State Hershey Medical Center and Associate Director for Translational Research at the Penn State Hershey Cancer Institute. "In the future, it may be possible to use specific identified tumor-infiltrating BMDCs to deliver therapeutic⁸ cargo⁹."

A first group of mice expressing a fluorescence gene¹⁰ served as donors¹¹ of the bone marrow cells. A second group of mice, whose marrow had been destroyed by radiation, were injected with the donated fluorescent¹² bone marrow. The transplanted bone marrow cells were allowed to proliferate¹³ for 8 weeks. Then, colon¹⁴ cancer cells were injected into the same mice and tumors formed over the next 3 weeks.

Monitoring tumor growth by optical imaging, researchers found that the tumors contained numerous types of BMDCs. Notably¹⁵ they also found that tumor growth is reduced in animals that received the bone marrow transplants, compared with untransplanted host mice.

According to the authors, cancer has long been viewed as a disease in which transformed cells grow and invade tissues. However, they believe that it is becoming clear that cancer is a more complex disease in a heterogeneous¹⁶（多相的，异种的） microenvironment where many cellular¹⁷ interactions are occurring in the malignant¹⁸ tissue.

"This type of mouse model allows scientists to actually see in living color the complicated relationships and interplay between the…tumor's own cells and the immune system cells within the host…" said El-Deiry, who is also an American Cancer Society Research Professor. He added: "this ongoing¹⁹ war on cancer within this tumor microenvironment has surprising twists and turns." El-Deiry and his colleagues hope to steer²⁰ patient outcomes "with additional treatments that can help [them] overcome the cancer."