新方法利用干细胞培养心肌细胞

时间：2012-06-21 06:02:10

（单词翻译:单击）

A cutting-edge method developed at the University of Michigan Center for Arrhythmia Research successfully uses stem cells to create heart cells capable of mimicking1 the heart's crucial squeezing action. The cells displayed activity similar to most people's resting heart rate. At 60 beats per minute, the rhythmic2 electrical impulse transmission of the engineered cells in the U-M study is 10 times faster than in most other reported stem cell studies.

An image of the electrically stimulated3 cardiac（心脏的） cells is displayed on the cover of the current issue of Circulation Research, a publication of the American Heart Association.

For those suffering from common, but deadly heart diseases, stem cell biology represents a new medical frontier.

The U-M team of researchers is using stem cells in hopes of helping4 the 2.5 million people with an arrhythmia, an irregularity in the heart's electrical impulses that can impair5 the heart's ability to pump blood.

"To date, the majority of studies using induced pluripotent stem cell-derived cardiac muscle cells have focused on single cell functional6 analysis," says senior author Todd J. Herron, Ph.D., an assistant research professor in the Departments of Internal Medicine and Molecular7 & Integrative Physiology8 at the U-M.

"For potential stem cell-based cardiac regeneration therapies for heart disease, however, it is critical to develop multi-cellular tissue like constructs that beat as a single unit," says Herron.

Their objective, working with researchers at the University of Oxford9, Imperial College and University of Wisconsin, included developing a bioengineering approach, using stem cells generated from skin biopsies, which can be used to create large numbers of cardiac muscle cells that can transmit uniform electrical impulses and function as a unit.

Furthermore, the team designed a fluorescent10 imaging platform using light emitting diode (LED) illumination to measure the electrical activity of the cells.

"Action potential and calcium11 wave impulse propogation trigger each normal heart beat, so it is imperative12（必要的） to record each parameter13 in bioengineered human cardiac patches," Herron says.


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点击收听单词发音收听单词发音  

1 mimicking ac830827d20b6bf079d24a8a6d4a02ed     
v.（尤指为了逗乐而）模仿( mimic的现在分词 )；酷似
参考例句：
  • She's always mimicking the teachers. 她总喜欢模仿老师的言谈举止。
  • The boy made us all laugh by mimicking the teacher's voice. 这男孩模仿老师的声音，逗得我们大家都笑了。 来自辞典例句
2 rhythmic rXexv     
adj.有节奏的，有韵律的
参考例句：
  • Her breathing became more rhythmic.她的呼吸变得更有规律了。
  • Good breathing is slow,rhythmic and deep.健康的呼吸方式缓慢深沉而有节奏。
3 stimulated Rhrz78     
a.刺激的
参考例句：
  • The exhibition has stimulated interest in her work. 展览增进了人们对她作品的兴趣。
  • The award has stimulated her into working still harder. 奖金促使她更加努力地工作。
4 helping 2rGzDc     
n.食物的一份&adj.帮助人的，辅助的
参考例句：
  • The poor children regularly pony up for a second helping of my hamburger. 那些可怜的孩子们总是要求我把我的汉堡包再给他们一份。
  • By doing this, they may at times be helping to restore competition. 这样一来, 他在某些时候,有助于竞争的加强。
5 impair Ia4x2     
v.损害，损伤；削弱，减少
参考例句：
  • Loud noise can impair your hearing.巨大的噪音有损听觉。
  • It can not impair the intellectual vigor of the young.这不能磨灭青年人思想活力。
6 functional 5hMxa     
adj.为实用而设计的，具备功能的，起作用的
参考例句：
  • The telephone was out of order,but is functional now.电话刚才坏了，但现在可以用了。
  • The furniture is not fancy,just functional.这些家具不是摆着好看的，只是为了实用。
7 molecular mE9xh     
adj.分子的；克分子的
参考例句：
  • The research will provide direct insight into molecular mechanisms.这项研究将使人能够直接地了解分子的机理。
  • For the pressure to become zero, molecular bombardment must cease.当压强趋近于零时，分子的碰撞就停止了。
8 physiology uAfyL     
n.生理学，生理机能
参考例句：
  • He bought a book about physiology.他买了一本生理学方面的书。
  • He was awarded the Nobel Prize for achievements in physiology.他因生理学方面的建树而被授予诺贝尔奖。
9 Oxford Wmmz0a     
n.牛津（英国城市）
参考例句：
  • At present he has become a Professor of Chemistry at Oxford.他现在已是牛津大学的化学教授了。
  • This is where the road to Oxford joins the road to London.这是去牛津的路与去伦敦的路的汇合处。
10 fluorescent Zz2y3     
adj.荧光的，发出荧光的
参考例句：
  • They observed the deflections of the particles by allowing them to fall on a fluorescent screen.他们让粒子落在荧光屏上以观察他们的偏移。
  • This fluorescent lighting certainly gives the food a peculiar color.这萤光灯当然增添了食物特别的色彩。
11 calcium sNdzY     
n.钙(化学符号Ca)
参考例句：
  • We need calcium to make bones.我们需要钙来壮骨。
  • Calcium is found most abundantly in milk.奶含钙最丰富。
12 imperative BcdzC     
n.命令，需要；规则；祈使语气；adj.强制的；紧急的
参考例句：
  • He always speaks in an imperative tone of voice.他老是用命令的口吻讲话。
  • The events of the past few days make it imperative for her to act.过去这几天发生的事迫使她不得不立即行动。
13 parameter eK4xZ     
n.参数，参量
参考例句：
  • It is the parameter of distribution.这就是分布参数。
  • One parameter which always comes into play is the national economy.国民经济是一个经常起作用的参量。

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