离散犹太人整体基因图谱绘制成功

A new genetic¹ analysis focusing on Jews from North Africa has provided an overall genetic map of the Jewish Diasporas. The findings support the historical record of Middle Eastern Jews settling in North Africa during Classical Antiquity², proselytizing³（改变宗教信仰） and marrying local populations, and, in the process, forming distinct populations that stayed largely intact for more than 2,000 years. The study, led by researchers at Albert Einstein College of Medicine of Yeshiva University, was published online August 6 in the Proceedings⁴ of the National Academy of Sciences. "Our new findings define North African Jews, complete the overall population structure for the various groups of the Jewish Diaspora, and enhance the case for a biological basis for Jewishness," said study leader Harry⁵ Ostrer, M.D., professor of pathology, of genetics and of pediatrics（小儿科） at Einstein and director of genetic and genomic testing for the division of clinical pathology at Montefiore Medical Center. Dr. Ostrer noted⁶ that obtaining a comprehensive genetic fingerprint⁷ of various Jewish subpopulations can help reveal genetic links to heart disease, cancer, diabetes⁸ and other common diseases.

 

In a previous genetic analysis, the researchers showed that modern-day Sephardic (Greek and Turkish), Ashkenazi (Eastern European) and Mizrahi (Iranian, Iraqi and Syrian) Jews that originated in Europe and the Middle East are more related to each other than to their contemporary non-Jewish neighbors, with each group forming its own cluster within the larger Jewish population. Further, each group demonstrated Middle-Eastern ancestry⁹ and varying degrees of mixing with surrounding populations. Two of the major Jewish populations -- Middle Eastern and European Jews -- were found to have diverged¹⁰ from each other approximately 2,500 years ago.

 

The current study extends that analysis to North African Jews -- the second largest Jewish Diaspora group. Their relatedness to each other, to other Jewish Diaspora groups, and to their non-Jewish North African neighbors had not been well defined. The study also included members of Jewish communities in Ethiopia, Yemen and Georgia. In all, the researchers analyzed¹¹ the genetic make-up of 509 Jews from 15 populations along with genetic data on 114 individuals from seven North African non-Jewish populations.

 

North African Jews exhibited a high degree of endogamy, or marriage within their own religious and cultural group in accordance with custom. Two major subgroups within this overall population were identified: Moroccan/Algerian Jews and Djerban (Tunisian)/Libyan Jews. The two subgroups varied¹² in their degree of European mixture, with Moroccan/Algerian Jews tending to be more related to Europeans -- most likely stemming from the expulsion（驱逐，开除） of Sephardic Jews from Spain during the Inquisition, starting in 1492. Ethiopian and Yemenite Jewish populations also formed distinctive¹³ genetically¹⁴ linked clusters, as did Georgian Jews.

 

The research was supported by grants from the Lewis and Rachel Rudin Foundation; the Iranian-American Jewish Federation¹⁵ of New York; the U.S.-Israel Binational Science Foundation; National Cancer Institute (CA121852) of the National Institutes of Health; and Ruth and Sidney Lapidus.

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