A new study of gut¹ bacteria in premature² infants reveals the vast scope of the problem of antibiotic³ resistance and gives new insight into the extreme vulnerability of these young patients, according to researchers at Washington University School of Medicine in St. Louis. The study appears online March 7 in the journal Nature Microbiology.

 

The gut microbiome has emerged in recent years as a vital player in human health, affecting factors as diverse as nutritional⁴ status, bone development and immune function. The new study shows that the microbes colonizing⁵ the gastrointestinal tracts⁶ of babies born prematurely⁷ are not health-promoting or even benign⁸ organisms, but close relatives of bacteria known to cause hospital-acquired infections, including Escherichia coli (E. coli), Klebsiella and Enterobacter.

 

The researchers sequenced all of the DNA⁹ in the bacterial¹⁰ communities living in the preterm babies' guts¹¹. Using new techniques they developed, the investigators¹² identified almost 800 genes¹³ in these bacterial communities that confer resistance to antibiotics¹⁴. They noted¹⁵ that about 80 percent of these genes had not previously¹⁶ been associated with antibiotic resistance.

 

"Our study demonstrates that even well-studied bacteria -- the ones that we know cause disease or their close relatives -- have many genes associated with antibiotic resistance that have not been characterized before," said senior author Gautam Dantas, PhD, associate professor of pathology and immunology. "Premature babies do not always get bacterial infections that need treatment, but we have known for a long time that they are at higher risk for infection than babies born full term. Now, we know that preterm-infant guts are attracting exactly the wrong kinds of bacteria."

 

Because of this increased risk of infection, almost all preterm infants cared for in neonatal intensive care units (NICUs) receive antibiotics in the first two days of life, regardless of their health status. And a majority of those receive many more days of treatment.

 

"Extremely preterm infants often have multiple medical problems, with symptoms of prematurity¹⁷ overlapping¹⁸ with other conditions like infection," said co-author Barbara B. Warner, MD, a professor of pediatrics and neonatologist at St. Louis Children's Hospital. "The conventional wisdom has been antibiotics can't hurt and they might help. But our new study demonstrates that wide-scale use of antibiotics in this population does not come without cost."

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