生命的循环
文章来源: 文章作者: 发布时间:2007-03-14 01:08 字体: [ ]  进入论坛
(单词翻译:双击或拖选)

Facing death, Jeff Cross and Lily Cheng had run out of options. But a rare "domino" liver transplant, involving a living donor1, gave both a future.

   面对死亡,杰夫·克罗斯和程莉莉已经没有其他选择了。但是一个罕见的"多米诺"式肝脏移植(涉及到一位活人器官捐献者),却给两人带来了新的生机。

 Circle of Life

Since last spring, Jeff Cross, 29, had been tormented2 by night sweats, a side effect of the rare genetic4 illness that threatened to kill him unless he got a new liver.

    生命的循环

   从去年春天起,29岁的杰夫·克罗斯天天被盗汗所困扰,这源于一种罕见的基因遗传病变,除非他获得一个新的肝脏,否则疾病将威胁他的生命。

Cross's disease, familial amyloidosis, prevents the liver from breaking down a protein called transthyretin. It takes about three decades for the substance to accumulate to dangerous levels, at which point it can destroy the victim's nerves and organs. Because of his background he had no idea that he carried a deadly gene3. Born is South Korea, he was adopted as a 4-year-old orphan5 by Peter Cross, and his wife, Margaret. After receiving a degree in economics from the University of California in 1995, Cross went to work in customer service for a investment firm in San Mateo. There he met JoAnna Poblete, now 27. In March 1998 the couple moved in together, and in August '99 they relocated to Los Angeles. But Cross soon developed a cough so violent it made him vomit6. His left foot hurt so badly that he could barely walk. Then he lost 25 lbs. and most of the sight in his right eye.

    克罗斯患有一种其家族特有的淀粉样变性疾病,它使肝脏无法分解一种叫做转体基因的蛋白。这种物质积累约30年方可达到危险水平,届时它将破坏患者的神经系统和器官。由于他特殊的成长经历,他并不知道自己携有致命基因。他出生在南韩,4岁时被彼得·克罗斯和他的妻子玛格丽特收养,当时他已经是一个孤儿。1995年获得加利福尼亚大学经济学学位后,克罗斯在圣马特奥的一家投资公司的顾客服务部工作。在那里他结识了现已27岁的乔安娜·波夫莱特。1998年3月,他们俩搬到一起,翌年8月乔迁至洛杉矶。不久克罗斯患了咳嗽症,他咳得非常厉害并时常呕吐。他的左脚剧痛难忍导致行走困难。接着体重锐减25磅,右眼失去大部分视力。

 Then in April Dr. Marc O.Yoshizumi, professor of ophthalmology at UCLA's Jules Stein Eye Institute, suggested Cross get tested for amyloidosis. Initially7 Cross was diagnosed with a different, incurable8 form of the disease, which would likely have killed him by age 40. In search of a second opinion, Poblete tracked down amyloidosis experts on the Internet. Dr. Morie Gertz, chairman of the hematology division at the Mayo Clinic responded, and after Cross flew out for an exam,Gertz delivered a new conclusion:familial amyloidosis, which affects about 1 in 4 million people and can be cured with a new liver." We were elated," Cross says.

    4月,加利福尼亚大学洛杉矶分校朱尔斯·斯坦视力协会眼科教授马克·欧·喜纯医生建议克罗斯就淀粉样变性做测试。最初克罗斯被诊断为患有另一种不可治愈的疾病,最多只能活到40岁。为寻求其他专家的不同意见,波夫莱特在网上查询淀粉样变性方面的专家。梅奥诊所血液部主任莫里埃·格茨医生回答了她的问题。当克罗斯做了一次抽血检测后,格茨提出了一个新的结论:家族淀粉样变性,其发病几率大约是400万分之1,可采用肝脏移植来治愈。克罗斯说:"我们听后非常高兴。"

That joy proved short-lived. Cross's protein-damaged heart was in such bad shape, doctors said, that it could give out within six months. Yet because his liver was functioning well, aside from its one defect, he would be a lower priority than many candidates for a cadaverliver transplant. A desperate Poblete e-mailed 100 friends and family members, asking if anyone with the same blood type as Cross, O positive, would be willing to help.

   但那份欢乐是短暂的。医生们说,因蛋白质坏损,克罗斯的心脏状况极差,将会在6个月内衰竭。由于他的肝脏除了自身遗传缺陷外,运转功能仍然良好,因此在众多等待肝脏移植的候选人中并不具有任何优先权。绝望的波夫莱特向100名朋友和家人发出电子邮件,询问是否有像克罗斯一样是O型血的人愿意伸出援助之手。

No one in Cross's adopted family proved a match, so Doug Andrews stepped forward. Andrews is youth pastor10 of the First Baptist Church of San Mateo. Though he wasn't close to the ailing11 man, his wife, Krissie, 28, a product manager for a medical-device company, had been pals12 with Cross since kindergarten.

   在收养克罗斯的家庭成员中无人与其血型相配,于是道格·安德鲁斯挺身相助。安德鲁斯是圣马蒂奥浸礼会的年轻牧师。他本人与病魔缠身的克里斯并不熟识,但他28岁的妻子--一位医疗器械公司的产品经理,从幼儿园时起就同克罗斯是好朋友。

 In so doing he gave 43-year-old Lily Cheng a new chance at life as well. Born in Beijing, Cheng was a professional dancer before getting married and having a son, Jack13, now 15. In 1989 she got into the import business and three years later moved to the U.S.. After divorcing her husband in 1996, she settled with Jack in an apartment outside L.A. and went to work for an import-export business that requires her to make frequent trips to China.

   安德鲁斯的义举还给43岁的程莉莉带来了一个新生的机会。程莉莉出生在北京,在她结婚并生下今年已15岁的杰克之前,曾是一名专业舞蹈演员。1989年她开始做进口生意,3年后搬到美国。1996年她与其丈夫离婚后,同儿子杰克住在洛杉矶市郊的一座公寓中,为了进出口生意需要经常往来中国。

 

It was on one such excursion in July that Cheng, who still felt more comfortable with the medical system in her native land, decided14 to get a routine physical." The doctor saw something on my liver right away," says Cheng. Although she still had no symptoms, specialists back in the U.S. delivered a grim prognosis. Says Dr. Busuttil:" She would probably have been dead within a year." By the time she became eligible15 for a cadaver9 liver, the cancer would have spread throughout her body.

   这是7月里的一个短期旅程,程莉莉来到她的出生地北京,由于对当地的医疗体制更适应一些,于是决定做一次常规体检。程说:"医生立即在我的肝脏上发现了问题。尽管她当时尚未有症状,但回到美国后专家对其病情的预测却令人担忧。比叙蒂医生说:"她可能在一年内离开这个世界。"待到她得到一个适合的活体肝脏时,肝癌细胞早已扩散到全身。

 Even harder than hearing that news was breaking it to her only child. " She said she wanted to see me grow up and she loves me very much," Jack recalls. " I don't usually cry, but I cried when she told me." Cheng then returned to China to see her parents, for what she feared might be the last time. There she received the call from UCLA telling her she was a perfect candidate for Cross's liver, since it was similar in size to hers and their blood types matched. And because Cross's amyloidosis was so slow-acting, she would be in her 70s before symptoms set in.

  比这个更痛苦的是把这个消息告诉她惟一的孩子。杰克回忆道:"她说她想看着我长大,她非常地爱我。我平常不爱哭,但当时我哭得很伤心。"程接着回到中国去看望双亲,她恐怕这可能是最后一次了。但在北京她接到了来自加利福尼亚大学洛杉矶分校的电话,告诉她克罗斯的肝脏同她的肝脏大小相似,且他们的血型相配,她是接受克罗斯肝脏移植的完美候选人。由于克罗斯的淀粉样变性发展缓慢,疾病发作之前她将是70多岁的人了。

With Andrews, Cross and Cheng lined up, doctors scheduled the triple surgery. The surgeons would not be sure until they opened up Andrews that his liver was healthy enough to be transplanted. Even if it was, Cross had a 40 percent chance of dying on the operating table because his heart had grown so weak.

 安德鲁斯,克罗斯和程将以此为序接受医生们计划的3人一组的外科手术。在外科医师打开安德鲁斯的体腔确定其肝脏健康可进行移植前,大家对这次手术的成功性都难以把握。而且即便如此,由于克罗斯的心脏十分虚弱,他死在手术台上的概率达40%。

  But it was Cheng who carried the most risk. Not only did doctors fear her cancer might have already spread beyond her liver -- thereby16 rendering17 a transplant futile18 -- but two nights before the surgery, she came down with a cold. Because transplants weaken the immune system, they cannot be performed on sick patients.

   然而程的风险最大,医生担心她的癌细胞已经扩散,会使移植徒劳无功,更糟糕的是在手术前两个晚上,她患了感冒。由于移植会使免疫系统变弱,病人在此情况下不能施行手术。

 

 Cheng immediately checked into the hospital, and doctors had her infection-free within 24 hours. She met Cross and Andrews for the first time when they arrived on Oct. 1, trading jokes and encouragement with the men in Cross's room.

At 5 a.m.on Oct.2,Cross and Andrews were wheeled into separate operating rooms,each staffed by a team of eight doctors and nurses.(Cheng would follow at 9 a.m.)First Dr.Ghobrial opened up Andrews. After seeing that his liver was in fine shape, Ghobrial sliced off a little more than half of the organ's right side. In the room down the hall, Dr. Busuttil began to remove Cross's liver.

程立即住进医院,医生们在24小时内将其感冒治好。克罗斯和安德鲁斯于10月1日到达,程与他们第一次见面,她轻松地开着玩笑并表示鼓励。

10月2日凌晨5点,克罗斯和安德鲁斯分别被送进手术室,每个手术小组配备8名医生和护士(程的手术将于上午9:00开始)。贾布里勒医生为安德鲁斯实施手术。在确认他的肝脏健康完好,贾布里勒医生切下了右边肝脏的多半部分。在大厅南侧的房间里,比叙蒂医生开始切除克罗斯的肝脏。

 

 At 11:30 a.m.Busuttil connected the partial liver from Andrews to Cross's now-empty liver cavity, stitching together veins19, arteries20 and bile ducts. An hour later, after receiving word that Cheng's cancer was limited to her liver, Ghobrial moved to the third operating room to help implant21 Cross's liver into Cheng.

By 5:30 p.m. all three patients were in recovery. " There are often hitches22 in surgery," says Busuttil, " but with this particular one, it was like clockwork." Which is exactly what Cross's fiancé e told him as soon as he woke up. " Jeff, you made it, you're okay," said Poblete. Cross, on a respirator, responded the only way he could -- with tears.

   上午11:30,比叙蒂将安德鲁斯的部分肝脏植入克罗斯的肝腔,缝合静脉、动脉和胆管。1小时以后传来消息说,程的肿瘤没有从肝脏扩散。贾布里勒来到第三间手术室,帮忙将克罗斯的肝脏移植到程身上。

 

  下午5:30,3名病人都处于康复状态。比叙蒂说:"在外科手术中经常会有事故发生。但是这个特殊的手术却像时钟一样精确。"当克罗斯刚刚醒来,他的未婚妻波夫莱特告诉他说:"杰夫,手术成功了,你很好。"克罗斯戴着一个呼吸器,只能用热泪作为回应。

A few complications cropped up post-surgery. Andrews spent an extra four days in the hospital until the nerves in his liver began functioning fully23, while Cheng's bile duct had to be restitched after it developed a slight leak. Cheng, meanwhile, has a 60 to 70 percent chance of surviving five years cancer-free. And though she, like Cross, will take immunosuppressant drugs for the rest of her life to prevent rejection24 of the new liver, she's thrilled to have been given more time with her son. "Every time I see Jack," she says, " I feel grateful."

    手术后出现了一些并发症。安德鲁斯因此在医院又多住4天,直到其肝脏的神经开始完全正常工作。而程的胆管因出现泄漏而不得不再次缝合。程有60%至70%的可能在5年内不会出现癌症。尽管她像克罗斯一样,为了防止新肝脏的排异性,将终身服用抑制免疫力之药物。但对于能有更长的时间同她儿子在一起,她仍感到很兴奋。她说:"每当看到杰克,我就心怀感激。"

 

 Cross, too, is counting his blessings25. He was planning to return to work this month, and because doctors give him an 85 percent chance of surviving the next year, he and Poblete feel confident enough to plan a fall wedding. His eyesight has been restored, following a separate operation, and now Cross is undergoing physical therapy three times a week to rebuild the strength in his nerve-damaged feet. That should allow him to walk down the aisle26 and to fulfil another dream of Poblete's." All I've ever wanted,"she says," is for him to be able to dance all night.

    克罗斯也不断地作感恩祷告。他计划本月重返工作岗位。由于医生告诉他有85%的机会活过明年,他和波夫莱特充满信心,计划举行秋季婚礼。又经过一次手术后,他的视力恢复了。现在克罗斯一周3次接受理疗,以使他神经受损的双足逐渐恢复力量,能够沿走廊漫步,进而实现波夫莱特的另一个梦想。她说:"我曾经梦想的,就是他能够整夜地跳舞。"马宁 摘译自People



点击收听单词发音收听单词发音  

1 donor dstxI     
n.捐献者;赠送人;(组织、器官等的)供体
参考例句:
  • In these cases,the recipient usually takes care of the donor afterwards.在这类情况下,接受捐献者以后通常会照顾捐赠者。
  • The Doctor transplanted the donor's heart to Mike's chest cavity.医生将捐赠者的心脏移植进麦克的胸腔。
2 tormented b017cc8a8957c07bc6b20230800888d0     
饱受折磨的
参考例句:
  • The knowledge of his guilt tormented him. 知道了自己的罪责使他非常痛苦。
  • He had lain awake all night, tormented by jealousy. 他彻夜未眠,深受嫉妒的折磨。
3 gene WgKxx     
n.遗传因子,基因
参考例句:
  • A single gene may have many effects.单一基因可能具有很多种效应。
  • The targeting of gene therapy has been paid close attention.其中基因治疗的靶向性是值得密切关注的问题之一。
4 genetic PgIxp     
adj.遗传的,遗传学的
参考例句:
  • It's very difficult to treat genetic diseases.遗传性疾病治疗起来很困难。
  • Each daughter cell can receive a full complement of the genetic information.每个子细胞可以收到遗传信息的一个完全补偿物。
5 orphan QJExg     
n.孤儿;adj.无父母的
参考例句:
  • He brought up the orphan and passed onto him his knowledge of medicine.他把一个孤儿养大,并且把自己的医术传给了他。
  • The orphan had been reared in a convent by some good sisters.这个孤儿在一所修道院里被几个好心的修女带大。
6 vomit TL9zV     
v.呕吐,作呕;n.呕吐物,吐出物
参考例句:
  • They gave her salty water to make her vomit.他们给她喝盐水好让她吐出来。
  • She was stricken by pain and began to vomit.她感到一阵疼痛,开始呕吐起来。
7 initially 273xZ     
adv.最初,开始
参考例句:
  • The ban was initially opposed by the US.这一禁令首先遭到美国的反对。
  • Feathers initially developed from insect scales.羽毛最初由昆虫的翅瓣演化而来。
8 incurable incurable     
adj.不能医治的,不能矫正的,无救的;n.不治的病人,无救的人
参考例句:
  • All three babies were born with an incurable heart condition.三个婴儿都有不可治瘉的先天性心脏病。
  • He has an incurable and widespread nepotism.他们有不可救药的,到处蔓延的裙带主义。
9 cadaver usfzG     
n.尸体
参考例句:
  • Examination of a cadaver is to determine the cause of death.尸体解剖是为了确认死亡原因。
  • He looked down again at the gaping mouth of the cadaver.他的眼光不由自主地又落到了死人张大的嘴上。
10 pastor h3Ozz     
n.牧师,牧人
参考例句:
  • He was the son of a poor pastor.他是一个穷牧师的儿子。
  • We have no pastor at present:the church is run by five deacons.我们目前没有牧师:教会的事是由五位执事管理的。
11 ailing XzzzbA     
v.生病
参考例句:
  • They discussed the problems ailing the steel industry. 他们讨论了困扰钢铁工业的问题。
  • She looked after her ailing father. 她照顾有病的父亲。
12 pals 51a8824fc053bfaf8746439dc2b2d6d0     
n.朋友( pal的名词复数 );老兄;小子;(对男子的不友好的称呼)家伙
参考例句:
  • We've been pals for years. 我们是多年的哥们儿了。
  • CD 8 positive cells remarkably increased in PALS and RP(P CD8+细胞在再生脾PALS和RP内均明显增加(P 来自互联网
13 jack 53Hxp     
n.插座,千斤顶,男人;v.抬起,提醒,扛举;n.(Jake)杰克
参考例句:
  • I am looking for the headphone jack.我正在找寻头戴式耳机插孔。
  • He lifted the car with a jack to change the flat tyre.他用千斤顶把车顶起来换下瘪轮胎。
14 decided lvqzZd     
adj.决定了的,坚决的;明显的,明确的
参考例句:
  • This gave them a decided advantage over their opponents.这使他们比对手具有明显的优势。
  • There is a decided difference between British and Chinese way of greeting.英国人和中国人打招呼的方式有很明显的区别。
15 eligible Cq6xL     
adj.有条件被选中的;(尤指婚姻等)合适(意)的
参考例句:
  • He is an eligible young man.他是一个合格的年轻人。
  • Helen married an eligible bachelor.海伦嫁给了一个中意的单身汉。
16 thereby Sokwv     
adv.因此,从而
参考例句:
  • I have never been to that city,,ereby I don't know much about it.我从未去过那座城市,因此对它不怎么熟悉。
  • He became a British citizen,thereby gaining the right to vote.他成了英国公民,因而得到了投票权。
17 rendering oV5xD     
n.表现,描写
参考例句:
  • She gave a splendid rendering of Beethoven's piano sonata.她精彩地演奏了贝多芬的钢琴奏鸣曲。
  • His narrative is a super rendering of dialect speech and idiom.他的叙述是方言和土语最成功的运用。
18 futile vfTz2     
adj.无效的,无用的,无希望的
参考例句:
  • They were killed,to the last man,in a futile attack.因为进攻失败,他们全部被杀,无一幸免。
  • Their efforts to revive him were futile.他们对他抢救无效。
19 veins 65827206226d9e2d78ea2bfe697c6329     
n.纹理;矿脉( vein的名词复数 );静脉;叶脉;纹理
参考例句:
  • The blood flows from the capillaries back into the veins. 血从毛细血管流回静脉。 来自《简明英汉词典》
  • I felt a pleasant glow in all my veins from the wine. 喝过酒后我浑身的血都热烘烘的,感到很舒服。 来自《简明英汉词典》
20 arteries 821b60db0d5e4edc87fdf5fc263ba3f5     
n.动脉( artery的名词复数 );干线,要道
参考例句:
  • Even grafting new blood vessels in place of the diseased coronary arteries has been tried. 甚至移植新血管代替不健康的冠状动脉的方法都已经试过。 来自《简明英汉词典》
  • This is the place where the three main arteries of West London traffic met. 这就是伦敦西部三条主要交通干线的交汇处。 来自《简明英汉词典》
21 implant YaBxT     
vt.注入,植入,灌输
参考例句:
  • A good teacher should implant high ideals in children.好教师应该把高尚理想灌输给孩子们。
  • The operation to implant the artificial heart took two hours.人工心脏植入手术花费了两小时。
22 hitches f5dc73113e681c579f78248ad4941e32     
暂时的困难或问题( hitch的名词复数 ); 意外障碍; 急拉; 绳套
参考例句:
  • He hitches a lift with a long - distance truck. 他搭上了一辆长途卡车。
  • One shoulder hitches upward in a shrug. 她肩膀绷紧,然后耸了耸。
23 fully Gfuzd     
adv.完全地,全部地,彻底地;充分地
参考例句:
  • The doctor asked me to breathe in,then to breathe out fully.医生让我先吸气,然后全部呼出。
  • They soon became fully integrated into the local community.他们很快就完全融入了当地人的圈子。
24 rejection FVpxp     
n.拒绝,被拒,抛弃,被弃
参考例句:
  • He decided not to approach her for fear of rejection.他因怕遭拒绝决定不再去找她。
  • The rejection plunged her into the dark depths of despair.遭到拒绝使她陷入了绝望的深渊。
25 blessings 52a399b218b9208cade790a26255db6b     
n.(上帝的)祝福( blessing的名词复数 );好事;福分;因祸得福
参考例句:
  • Afflictions are sometimes blessings in disguise. 塞翁失马,焉知非福。 来自《简明英汉词典》
  • We don't rely on blessings from Heaven. 我们不靠老天保佑。 来自《现代汉英综合大词典》
26 aisle qxPz3     
n.(教堂、教室、戏院等里的)过道,通道
参考例句:
  • The aisle was crammed with people.过道上挤满了人。
  • The girl ushered me along the aisle to my seat.引座小姐带领我沿着通道到我的座位上去。
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