红酒如何保护大脑免受中风危害
文章来源:未知 文章作者:meng 发布时间:2010-04-22 01:17 字体: [ ]  进入论坛
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Researchers at Johns Hopkins say they have discovered the way in which red wine consumption may protect the brain from damage following a stroke. Two hours after feeding mice a single modest(谦虚的,适度的) dose of resveratrol(白藜芦醇) , a compound found in the skins and seeds of red grapes, the scientists induced(引诱,说服) an ischemic(缺血的) stroke by essentially1 cutting off blood supply to the animals' brains. They found that the animals that had preventively ingested(咽下,摄取) the resveratrol suffered significantly less brain damage than the ones that had not been given the compound.

Sylvain Doré, Ph.D., an associate professor of anesthesiology(麻醉学) and critical care medicine and pharmacology(药物学,药理学) and molecular2 sciences at the Johns Hopkins University School of Medicine, says his study suggests that resveratrol increases levels of an enzyme3 (heme oxygenase血红素氧化酶) already known to shield nerve cells in the brain from damage. When the stroke hits, the brain is ready to protect itself because of elevated enzyme levels. In mice that lacked the enzyme, the study found, resveratrol had no significant protective effect and their brain cells died after a stroke.

"Our study adds to evidence that resveratrol can potentially build brain resistance to ischemic stroke," says Doré, the leader of the study, which appears online in the journal Experimental Neurology.

Red wine has gotten a lot of attention lately for its purported4 health benefits. Along with reducing stroke, moderate wine consumption has been linked to a lowered incidence of cardiovascular disease(心血管疾病,冠心病) — the so-called French paradox5(法国悖论) . Despite diets high in butter, cheese and other saturated6 fats(饱和脂肪) , the paradox goes, the French have a relatively7 low incidence of cardiovascular events, which some have attributed to the regular drinking of red wine.

Doré cautions against taking resveratrol supplements, available alongside vitamins and minerals and on websites touting8(兜售,招徕顾客) its benefits, because it is unclear whether such supplements could do harm or good. He has not tested resveratrol in clinical trials. And while resveratrol is found in red grapes, it's the alcohol in the wine that may be needed to concentrate the amounts of the beneficial compound. Doré also cautions that drinking alcohol carries risks along with potential benefits.

He also notes that even if further research affirms the benefits of red wine, no one yet knows how much would be optimal9 to protect the brain, or even what kind of red wine might be best, because not all types contain the same amount of resveratrol. More research is needed, he says.

Doré says his research suggests that the amount needed could end up being quite small because the suspected beneficial mechanism10 is indirect. "Resveratrol itself may not be shielding brain cells from free radical11 damage directly, but instead, resveratrol, and its metabolites(代谢物,代谢分子) , may be prompting the cells to defend themselves," he suggests.

"It's not likely that brain cells can have high enough local levels of resveratrol to be protective," he says. The resveratrol is needed to jump-start this protective enzymatic12 system that is already present within the cells. "Even a small amount may be sufficient," Doré says.

Doré says his ongoing13 research also suggests some therapeutic14 benefits to giving resveratrol to mice after a stroke to limit further neuronal(神经原的) damage.



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1 essentially nntxw     
adv.本质上,实质上,基本上
参考例句:
  • Really great men are essentially modest.真正的伟人大都很谦虚。
  • She is an essentially selfish person.她本质上是个自私自利的人。
2 molecular mE9xh     
adj.分子的;克分子的
参考例句:
  • The research will provide direct insight into molecular mechanisms.这项研究将使人能够直接地了解分子的机理。
  • For the pressure to become zero, molecular bombardment must cease.当压强趋近于零时,分子的碰撞就停止了。
3 enzyme cPozF     
n.酵素,酶
参考例句:
  • Above a certain temperature,the enzyme molecule will become unfolded.超过一定温度,酶分子将会展开。
  • An enzyme that dissolves the fibrin of blood clots.能溶解血凝块中的纤维的酶。
4 purported 31d1b921ac500fde8e1c5f9c5ed88fe1     
adj.传说的,谣传的v.声称是…,(装得)像是…的样子( purport的过去式和过去分词 )
参考例句:
  • the scene of the purported crime 传闻中的罪案发生地点
  • The film purported to represent the lives of ordinary people. 这部影片声称旨在表现普通人的生活。 来自《简明英汉词典》
5 paradox pAxys     
n.似乎矛盾却正确的说法;自相矛盾的人(物)
参考例句:
  • The story contains many levels of paradox.这个故事存在多重悖论。
  • The paradox is that Japan does need serious education reform.矛盾的地方是日本确实需要教育改革。
6 saturated qjEzG3     
a.饱和的,充满的
参考例句:
  • The continuous rain had saturated the soil. 连绵不断的雨把土地淋了个透。
  • a saturated solution of sodium chloride 氯化钠饱和溶液
7 relatively bkqzS3     
adv.比较...地,相对地
参考例句:
  • The rabbit is a relatively recent introduction in Australia.兔子是相对较新引入澳大利亚的物种。
  • The operation was relatively painless.手术相对来说不痛。
8 touting 4d75f17b3549c92164bbfc96b4ef2275     
v.兜售( tout的现在分词 );招揽;侦查;探听赛马情报
参考例句:
  • He's been touting his novel around publishers for years. 他几年来一直到处找出版商兜售自己的小说。 来自《简明英汉词典》
  • Technology industry leaders are touting cars as a hot area for growth. 科技产业领袖吹捧为增长热点地区的汽车。 来自互联网
9 optimal zmDzhM     
adj.最适宜的;最理想的;最令人满意的
参考例句:
  • What is the optimal mix of private and public property rights in natural resources?私人和国家的自然资源产权的最适宜的组合是什么?
  • Optimal path planning is a key link for the sailing contest.帆船最优行驶路径规划是帆船比赛取胜的关键环节。
10 mechanism zCWxr     
n.机械装置;机构,结构
参考例句:
  • The bones and muscles are parts of the mechanism of the body.骨骼和肌肉是人体的组成部件。
  • The mechanism of the machine is very complicated.这台机器的结构是非常复杂的。
11 radical hA8zu     
n.激进份子,原子团,根号;adj.根本的,激进的,彻底的
参考例句:
  • The patient got a radical cure in the hospital.病人在医院得到了根治。
  • She is radical in her demands.她的要求十分偏激。
12 enzymatic bd3713b8a9001c96e240f712d69d0355     
adj. 酶的
参考例句:
  • This chromoprotein has also been endowed with enzymatic properties. 这种色素蛋白也具有酶的特性。
  • It is of profound interest to elucidate the enzymatic activities in soil. 阐明土壤中酶的活性是有深远意义的。
13 ongoing 6RvzT     
adj.进行中的,前进的
参考例句:
  • The problem is ongoing.这个问题尚未解决。
  • The issues raised in the report relate directly to Age Concern's ongoing work in this area.报告中提出的问题与“关心老人”组织在这方面正在做的工作有直接的关系。
14 therapeutic sI8zL     
adj.治疗的,起治疗作用的;对身心健康有益的
参考例句:
  • Therapeutic measures were selected to fit the patient.选择治疗措施以适应病人的需要。
  • When I was sad,music had a therapeutic effect.我悲伤的时候,音乐有治疗效力。
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