Scientists have taken another important step toward understanding just how sticking needles into the body can ease pain. In a paper published online May 30 in Nature Neuroscience, a team at the University of Rochester Medical Center identifies the molecule¹ adenosine（腺苷酸） as a central player in parlaying（使增殖，充分利用） some of the effects of acupuncture²（针灸） in the body. Building on that knowledge, scientists were able to triple the beneficial effects of acupuncture in mice by adding a medication approved to treat leukemia（白血病） in people.

The research focuses on adenosine, a natural compound known for its role in regulating sleep, for its effects on the heart, and for its anti-inflammatory properties. But adenosine also acts as a natural painkiller³（止痛药） , becoming active in the skin after an injury to inhibit⁴ nerve signals and ease pain in a way similar to lidocaine（利多卡因） .

In the current study, scientists found that the chemical is also very active in deeper tissues affected⁵ by acupuncture. The Rochester researchers looked at the effects of acupuncture on the peripheral⁶ nervous system（周围神经系统） – the nerves in our body that aren't part of the brain and spinal⁷ cord. The research complements⁸ a rich, established body of work showing that in the central nervous system, acupuncture creates signals that cause the brain to churn out natural pain-killing endorphins.

The new findings add to the scientific heft（重量，重要性） underlying⁹ acupuncture, said neuroscientist Maiken Nedergaard, M.D., D.M.Sc., who led the research. Her team is presenting the work this week at a scientific meeting, Purines 2010, in Barcelona, Spain.

"Acupuncture has been a mainstay（支柱） of medical treatment in certain parts of the world for 4,000 years, but because it has not been understood completely, many people have remained skeptical¹⁰（怀疑的） ," said Nedergaard, co-director of the University's Center for Translational Neuromedicine, where the research was conducted.

"In this work, we provide information about one physical mechanism¹¹ through which acupuncture reduces pain in the body," she added.

To do the experiment, the team performed acupuncture treatments on mice that had discomfort¹² in one paw. The mice each received a 30-minute acupuncture treatment at a well known acupuncture point near the knee, with very fine needles rotated gently every five minutes, much as is done in standard acupuncture treatments with people.

The team made a number of observations regarding adenosine:
In mice with normal functioning levels of adenosine, acupuncture reduced discomfort by two-thirds.
In special "adenosine receptor knock-out mice" not equipped with the adenosine receptor, acupuncture had no effect.
When adenosine was turned on in the tissues, discomfort was reduced even without acupuncture.
During and immediately after an acupuncture treatment, the level of adenosine in the tissues near the needles was 24 times greater than before the treatment.

Once scientists recognized adenosine's role, the team explored the effects of a cancer drug called deoxycoformycin, which makes it harder for the tissue to remove adenosine. The compound boosted the effects of acupuncture treatment dramatically, nearly tripling the accumulation of adenosine in the muscles and more than tripling the length of time the treatment was effective.

"It's clear that acupuncture may activate¹³ a number of different mechanisms," said Josephine P. Briggs, M.D., director of the National Center for Complementary and Alternative Medicine at the National Institutes of Health. "This carefully performed study identifies adenosine as a new player in the process. It's an interesting contribution to our growing understanding of the complex intervention¹⁴ which is acupuncture," added Briggs, who is the spouse¹⁵ of co-author Jurgen Schnermann.