A new study from researchers in Canada and Sweden has shown that biosynthetic（生物合成的） corneas（角膜） can help regenerate¹ and repair damaged eye tissue and improve vision in humans. The results, from an early phase clinical trial with 10 patients, are published in the August 25th, 2010 issue of Science Translational Medicine. "This study is important because it is the first to show that an artificially fabricated（焊接的，组合的） cornea can integrate with the human eye and stimulate² regeneration," said senior author Dr. May Griffith of the Ottawa Hospital Research Institute, the University of Ottawa and Linköping University. "With further research, this approach could help restore sight to millions of people who are waiting for a donated human cornea for transplantation."

The cornea is a thin transparent³ layer of collagen（胶原） and cells that acts as a window into the eyeball. It must be completely transparent to allow the light to enter and it also helps with focus. Globally, diseases that lead to clouding of the cornea represent the most common cause of blindness. More than a decade ago, Dr. Griffith and her colleagues began developing biosynthetic corneas in Ottawa, Canada, using collagen produced in the laboratory and moulded into the shape of a cornea. After extensive laboratory testing, Dr. Griffith began collaborating⁴ with Dr. Per Fagerholm, an eye surgeon at Linköping University in Sweden, to provide the first-in-human experience with biosynthetic cornea implantation.

Together, they initiated⁶ a clinical trial in 10 Swedish patients with advanced keratoconus（圆锥形角膜） or central corneal scarring. Each patient underwent surgery on one eye to remove damaged corneal tissue and replace it with the biosynthetic cornea, made from synthetically⁷ cross-linked recombinant（重组） human collagen. Over two years of follow-up, the researchers observed that cells and nerves from the patients' own corneas had grown into the implant⁵, resulting in a "regenerated⁸" cornea that resembled normal, healthy tissue. Patients did not experience any rejection⁹ reaction or require long-term immune suppression, which are serious side effects associated with the use of human donor¹⁰ tissue. The biosynthetic corneas also became sensitive to touch and began producing normal tears to keep the eye oxygenated. Vision improved in six of the ten patients, and after contact lens fitting, vision was comparable to conventional corneal transplantation with human donor tissue.

"We are very encouraged by these results and by the great potential of biosynthetic corneas," said Dr. Fagerholm. "Further biomaterial enhancements and modifications¹¹ to the surgical¹² technique are ongoing¹³, and new studies are being planned that will extend the use of the biosynthetic cornea to a wider range of sight-threatening conditions requiring transplantation."