他汀类药物对小儿狼疮效用不大
文章来源:未知 文章作者:meng 发布时间:2010-11-08 03:57 字体: [ ]  进入论坛
(单词翻译:双击或拖选)

Lupus(狼疮,天狼座) puts children at higher risk for coronary artery1 disease(冠心病) when they become adults, but routinely using statins(他汀类药物) doesn't provide enough benefit to warrant their regular use in children and adolescents, according to the largest study of pediatric(小儿科的) lupus patients to date. Lupus is an autoimmune disease that causes widespread inflammation and organ damage. Children with lupus show early signs of atherosclerosis(动脉硬化) -- the fatty tissue buildup that is the precursor2 to clogged3 arteries4. Previous research also indicates risk for heart attack and stroke in premenopausal(绝经前期的) women with lupus is 50 times greater than women the same age without the disease.

"As treatments for lupus improve and kids live longer, they are more likely to develop significant heart disease," says Laura Schanberg, MD, a professor of pediatrics at Duke University Medical Center who presented the findings at the American College of Rheumatology meeting in Atlanta. "We wanted to find a way to lower their risk."

Statins were the obvious choice for investigation5 since they have proven effective at decreasing heart disease incidence in many adult populations. "We thought every child with lupus should routinely be put on statins," Schanberg says. "This study proves that's not the case.

"The statins had positive effects on CRP and lipid levels, and they appear to be safe and well tolerated," says Schanberg, "But their effect on atherosclerosis was not significant enough to warrant routine use."

Schanberg, of the Duke Clinical Research Institute, and Stanford University professor Christy Sandborg, MD, were the co-principal investigators6 of the Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) trial. It randomized 221 participants with pediatric lupus (ages 10 to 21) from 21 sites within the Childhood Arthritis7 and Rheumatology Research Alliance (CARRA) to two groups. One group received atorvastatin(阿托伐他汀) (Lipitor), the other received placebo8 for 36 months.

The researchers set out to determine if the use of statins resulted in a significant clinical difference that outweighed10 any potential risks. They used ultrasound techniques to detect thickening of the arterial wall of carotid arteries(颈动脉) . They also studied blood lipid levels, inflammation markers including C-reactive protein (CRP), and lupus disease activity measures.

"There are rare long-term risks associated with statins that outweigh9 the risks of using them routinely without proof of clinically significant benefit," Schanberg says.

Further analysis is needed to determine whether sub groups of the study participants might derive11 more benefit from statin therapy.

"We're not saying statins should never be used in kids with lupus," she says. "Rather, we showed that statins should not be routinely prescribed to children with lupus. A lot more information has to go into the decision, and further investigation will help us arrive at a more definitive12 answer."



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1 artery 5ekyE     
n.干线,要道;动脉
参考例句:
  • We couldn't feel the changes in the blood pressure within the artery.我们无法感觉到动脉血管内血压的变化。
  • The aorta is the largest artery in the body.主动脉是人体中的最大动脉。
2 precursor rPOx1     
n.先驱者;前辈;前任;预兆;先兆
参考例句:
  • Error is often the precursor of what is correct.错误常常是正确的先导。
  • He said that the deal should not be seen as a precursor to a merger.他说该笔交易不应该被看作是合并的前兆。
3 clogged 0927b23da82f60cf3d3f2864c1fbc146     
(使)阻碍( clog的过去式和过去分词 ); 淤滞
参考例句:
  • The narrow streets were clogged with traffic. 狭窄的街道上交通堵塞。
  • The intake of gasoline was stopped by a clogged fuel line. 汽油的注入由于管道阻塞而停止了。
4 arteries 821b60db0d5e4edc87fdf5fc263ba3f5     
n.动脉( artery的名词复数 );干线,要道
参考例句:
  • Even grafting new blood vessels in place of the diseased coronary arteries has been tried. 甚至移植新血管代替不健康的冠状动脉的方法都已经试过。 来自《简明英汉词典》
  • This is the place where the three main arteries of West London traffic met. 这就是伦敦西部三条主要交通干线的交汇处。 来自《简明英汉词典》
5 investigation MRKzq     
n.调查,调查研究
参考例句:
  • In an investigation,a new fact became known, which told against him.在调查中新发现了一件对他不利的事实。
  • He drew the conclusion by building on his own investigation.他根据自己的调查研究作出结论。
6 investigators e970f9140785518a87fc81641b7c89f7     
n.调查者,审查者( investigator的名词复数 )
参考例句:
  • This memo could be the smoking gun that investigators have been looking for. 这份备忘录可能是调查人员一直在寻找的证据。
  • The team consisted of six investigators and two secretaries. 这个团队由六个调查人员和两个秘书组成。 来自《简明英汉词典》
7 arthritis XeyyE     
n.关节炎
参考例句:
  • Rheumatoid arthritis has also been linked with the virus.风湿性关节炎也与这种病毒有关。
  • He spent three months in the hospital with acute rheumatic arthritis.他患急性风湿性关节炎,在医院住了三个月。
8 placebo placebo     
n.安慰剂;宽慰话
参考例句:
  • The placebo has been found to work with a lot of different cases.人们已发现安慰剂能在很多不同的病例中发挥作用。
  • The placebo effect refers to all the observable behaviors caused by placebo.安慰剂效应是指由安慰剂所引起的可观察的行为。
9 outweigh gJlxO     
vt.比...更重,...更重要
参考例句:
  • The merits of your plan outweigh the defects.你制定的计划其优点胜过缺点。
  • One's merits outweigh one's short-comings.功大于过。
10 outweighed ab362c03a68adf0ab499937abbf51262     
v.在重量上超过( outweigh的过去式和过去分词 );在重要性或价值方面超过
参考例句:
  • This boxer outweighed by his opponent 20 pounds. 这个拳击选手体重比他的对手重20磅。 来自《简明英汉词典》
  • She outweighed me by ten pounds, and sometimes she knocked me down. 她的体重超过我十磅,有时竟把我撞倒。 来自百科语句
11 derive hmLzH     
v.取得;导出;引申;来自;源自;出自
参考例句:
  • We derive our sustenance from the land.我们从土地获取食物。
  • We shall derive much benefit from reading good novels.我们将从优秀小说中获得很大好处。
12 definitive YxSxF     
adj.确切的,权威性的;最后的,决定性的
参考例句:
  • This book is the definitive guide to world cuisine.这本书是世界美食的权威指南。
  • No one has come up with a definitive answer as to why this should be so.至于为什么该这样,还没有人给出明确的答复。
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