UC Irvine researchers have discovered that circadian rhythms（生物周期） – the internal body clock – regulate fat metabolism¹. This helps explain why people burn fat more efficiently² at certain times of day and could lead to new pharmaceuticals³（药物） for obesity⁴, diabetes⁵ and energy-related illnesses. The study was headed by Paolo Sassone-Corsi, Donald Bren Professor and chair of pharmacology. A leading expert on circadian rhythms, he discovered many of the key molecular⁶ switches governing these biological processes. He and his colleagues found that one of these, a protein called PER2, directly controls PPAR-gamma, a protein essential for lipid（油脂） metabolism. Since circadian proteins are activated⁷ by 24-hour, light-dark patterns, PER2 turns on and off PPAR-gamma's metabolic⁸ capabilities⁹ at regular intervals¹⁰.

"What surprised us most, though, is that PER2 targets one specific amino acid（氨基酸） on the surface of the PPAR-gamma molecule," Sassone-Corsi said. "This kind of specificity is very rare in cell biology, which makes it exciting, because it presents us with a singular target for drug development."

Daniele Piomelli, Louise Turner Arnold Chair in Neurosciences at UCI, and Todd Leff, associate professor of pathology at Wayne State University in Detroit, collaborated¹¹ on the study, which appears this month in Cell Metabolism.

Twenty-four-hour circadian rhythms regulate fundamental biological and physiological¹² processes in almost all organisms. They anticipate environmental changes and adapt certain bodily functions to the appropriate time of day. Disruption of these cycles can profoundly influence human health and has been linked to obesity, diabetes, insomnia¹³（失眠） , depression, heart disease and cancer.

Last year, Sassone-Corsi helped discover that proteins involved with circadian rhythms and metabolism are intrinsically（本质地，内在地） linked and dependent upon each other to ensure that cells operate properly and remain healthy.