大豆中某天然物质可能治疗儿童遗传疾病
文章来源:未知 文章作者:meng 发布时间:2010-12-03 02:15 字体: [ ]  进入论坛
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Scientists from The University of Manchester say a naturally occurring chemical found in soy(大豆,酱油) could prove to be an effective new treatment for a fatal genetic1 disease that affects children. Dr Brian Bigger, from the University's MPS Stem Cell Research Laboratory, found that genistein(染料木素) derived2 from soya beans and licensed3 in the US as an osteoporosis(骨质疏松症) drug – had a dramatic effect on mice suffering from the human childhood disease Sanfilippo.

"Sanfilippo is an untreatable mucopolysaccharide (MPS黏多糖) disease affecting one in 89,000 children in the United Kingdom," said Dr Bigger, who is based in the School of Biomedicine.

"Children with Sanfilippo disease experience progressive deterioration4(恶化,退化) of mental function, similar to dementia, in early childhood, with other symptoms including severe behavioural problems, hyperactivity and ultimately death in early teens."

In the study, published in the journal Public Library of Science One, mice with Sanfilippo disease were fed with high doses of genistein over a nine-month period. Treated mice showed a significant delay in their mental decline, including a third reduction in the amount of excess sugars found in the brain as a result of the disease, and a sixth reduction in inflammation in the brain.

Importantly, the research, carried out with colleagues at St Mary's Hospital in Manchester, also showed that the hyperactivity and other abnormal behaviour normally seen in Sanfilippo mice were fully5 corrected by genistein treatment.

Professor Wraith6, a co-author on the study and consultant7 paediatrician(儿科专家) from Genetic Medicine in St Mary's Hospital, said "Sanfilippo is a disease where the genetic lack of an enzyme8 leads to a fault in the breakdown9 of complex sugars in the cell.

"This leads to storage of these undegraded complex sugars in cells, disturbances10 in brain function and ultimately to this profound mental deterioration that we see in the children with this condition. Manchester is a specialist centre for this type of genetic disease and as such we look after more than 100 patients from all over the UK and beyond."

The Manchester team, supported by the UK society for mucopolysaccharide diseases and the Manchester Biomedical Research Centre, hope to announce a placebo11 controlled clinical trial for patients with Sanfilippo disease in the near future.



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1 genetic PgIxp     
adj.遗传的,遗传学的
参考例句:
  • It's very difficult to treat genetic diseases.遗传性疾病治疗起来很困难。
  • Each daughter cell can receive a full complement of the genetic information.每个子细胞可以收到遗传信息的一个完全补偿物。
2 derived 6cddb7353e699051a384686b6b3ff1e2     
vi.起源;由来;衍生;导出v.得到( derive的过去式和过去分词 );(从…中)得到获得;源于;(从…中)提取
参考例句:
  • Many English words are derived from Latin and Greek. 英语很多词源出于拉丁文和希腊文。 来自《简明英汉词典》
  • He derived his enthusiasm for literature from his father. 他对文学的爱好是受他父亲的影响。 来自《简明英汉词典》
3 licensed ipMzNI     
adj.得到许可的v.许可,颁发执照(license的过去式和过去分词)
参考例句:
  • The new drug has not yet been licensed in the US. 这种新药尚未在美国获得许可。
  • Is that gun licensed? 那支枪有持枪执照吗?
4 deterioration yvvxj     
n.退化;恶化;变坏
参考例句:
  • Mental and physical deterioration both occur naturally with age. 随着年龄的增长,心智和体力自然衰退。
  • The car's bodywork was already showing signs of deterioration. 这辆车的车身已经显示出了劣化迹象。
5 fully Gfuzd     
adv.完全地,全部地,彻底地;充分地
参考例句:
  • The doctor asked me to breathe in,then to breathe out fully.医生让我先吸气,然后全部呼出。
  • They soon became fully integrated into the local community.他们很快就完全融入了当地人的圈子。
6 wraith ZMLzD     
n.幽灵;骨瘦如柴的人
参考例句:
  • My only question right now involves the wraith.我唯一的问题是关于幽灵的。
  • So,what you're saying is the Ancients actually created the Wraith?照你这么说,实际上是古人创造了幽灵?
7 consultant 2v0zp3     
n.顾问;会诊医师,专科医生
参考例句:
  • He is a consultant on law affairs to the mayor.他是市长的一个法律顾问。
  • Originally,Gar had agreed to come up as a consultant.原来,加尔只答应来充当我们的顾问。
8 enzyme cPozF     
n.酵素,酶
参考例句:
  • Above a certain temperature,the enzyme molecule will become unfolded.超过一定温度,酶分子将会展开。
  • An enzyme that dissolves the fibrin of blood clots.能溶解血凝块中的纤维的酶。
9 breakdown cS0yx     
n.垮,衰竭;损坏,故障,倒塌
参考例句:
  • She suffered a nervous breakdown.她患神经衰弱。
  • The plane had a breakdown in the air,but it was fortunately removed by the ace pilot.飞机在空中发生了故障,但幸运的是被王牌驾驶员排除了。
10 disturbances a0726bd74d4516cd6fbe05e362bc74af     
n.骚乱( disturbance的名词复数 );打扰;困扰;障碍
参考例句:
  • The government has set up a commission of inquiry into the disturbances at the prison. 政府成立了一个委员会来调查监狱骚乱事件。
  • Extra police were called in to quell the disturbances. 已调集了增援警力来平定骚乱。
11 placebo placebo     
n.安慰剂;宽慰话
参考例句:
  • The placebo has been found to work with a lot of different cases.人们已发现安慰剂能在很多不同的病例中发挥作用。
  • The placebo effect refers to all the observable behaviors caused by placebo.安慰剂效应是指由安慰剂所引起的可观察的行为。
TAG标签: children genetic disease soy
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