昆虫保幼激素研究有利于控制害虫
文章来源:未知 文章作者:enread 发布时间:2010-12-28 03:45 字体: [ ]  进入论坛
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Just as raging hormones2 are part of the process of a child's maturation through the teen years to adulthood3, juvenile4 hormones, a group of insect isoprenoids(类异戊二烯) , play an important role as butterflies, fruit flies and mosquitoes transform their body structures as they molt5 from larva to pupa(蛹) and then adults. Unlike humans, in insects the juvenile hormone1 inhibits6 development of adult characteristics until the insects reach a proper stage. Juvenile hormones also play a prominent role in regulating reproductive maturation in adult insects and synthetic7(合成的) juvenile hormone mimics8 have been widely used as pesticides9 for mosquito controls.

Virginia Tech researchers have discovered an important step in the activation10 of juvenile hormone target genes11. "Understanding the molecular12 details in the juvenile hormone signaling may lead to discovery of novel chemicals that target mosquitoes with more selectivity," said Jinsong Zhu, assistant professor of biochemistry with the Fralin Life Science Institute at Virginia Tech.

The research is reported in the early online edition of the Proceedings13 of the National Academy of Sciences the week of Dec. 27.

"The secretion14 of juvenile hormone is drastically(彻底地,激烈地) reduced in the final larval stage, as a result of which the larva is transformed into a pupa. While an insect protein, Methoprene-tolerant (Met), has been postulated15 as the top candidate for juvenile hormone receptor, it remains16 unclear how this protein is activated17 by juvenile hormone," said Zhu.

He and his group believe that studying the hormone-regulated reproduction have a better chance of elucidating18(阐明,说明) the molecular action of juvenile hormones. They discovered a protein partner for Met in the yellow fever mosquito Aedes aegypti. This protein, named FISC, forms a complex with Met when juvenile hormone is present. Binding19 of these two proteins to the regulatory regions of some juvenile hormone target genes is closely correlated with the expression levels of those target genes in the newly emerged adult mosquitoes. Reducing the protein levels of Met or FISC by genetic20 approaches leads to dampened expression of the juvenile hormone target genes, and decreased egg production after the female mosquitoes take a blood meal.

The study by Zhu's group clearly demonstrates that formation of Met-FISC complex is a critical step in juvenile hormone signaling pathway. Evidence presented in the Proceedings of the National Academy of Sciences paper also suggests that fruit flies use the same mechanism21 in mediating22 juvenile hormone responses during molting23.

Zhu is now collaborating24 with Professor David Bevan's group in the biochemistry department to analyze25 the structure-function relationship of the Met protein.



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1 hormone uyky3     
n.荷尔蒙,激素,内分泌
参考例句:
  • Hormone implants are used as growth boosters.激素植入物被用作生长辅助剂。
  • This hormone interacts closely with other hormones in the body.这种荷尔蒙与体內其他荷尔蒙紧密地相互作用。
2 hormones hormones     
n. 荷尔蒙,激素 名词hormone的复数形式
参考例句:
  • This hormone interacts closely with other hormones in the body. 这种荷尔蒙与体內其他荷尔蒙紧密地相互作用。
  • The adrenals produce a large per cent of a man's sex hormones. 肾上腺分泌人体的大部分性激素。
3 adulthood vKsyr     
n.成年,成人期
参考例句:
  • Some infantile actions survive into adulthood.某些婴儿期的行为一直保持到成年期。
  • Few people nowadays are able to maintain friendships into adulthood.如今很少有人能将友谊维持到成年。
4 juvenile OkEy2     
n.青少年,少年读物;adj.青少年的,幼稚的
参考例句:
  • For a grown man he acted in a very juvenile manner.身为成年人,他的行为举止显得十分幼稚。
  • Juvenile crime is increasing at a terrifying rate.青少年犯罪正在以惊人的速度增长。
5 molt Rj9yb     
n.换毛,脱皮,换毛期
参考例句:
  • The fourth time they molt,they change into pupae.换第四次皮时,它们蜕变成蛹。
  • This veterinary product is very effective in preventing animal molt.这种兽药对于防治兽类掉毛很有效。
6 inhibits 7fbb1ac5e38d9e83ed670404679a2310     
阻止,抑制( inhibit的第三人称单数 ); 使拘束,使尴尬
参考例句:
  • A small manufacturing sector inhibits growth in the economy. 制造业规模太小有碍经济增长。
  • His bad English inhibits him from speaking freely. 他英语学得不好,这使他不能表达自如。
7 synthetic zHtzY     
adj.合成的,人工的;综合的;n.人工制品
参考例句:
  • We felt the salesman's synthetic friendliness.我们感觉到那位销售员的虚情假意。
  • It's a synthetic diamond.这是人造钻石。
8 mimics f8207fb5fa948f536c5186311e3e641d     
n.模仿名人言行的娱乐演员,滑稽剧演员( mimic的名词复数 );善于模仿的人或物v.(尤指为了逗乐而)模仿( mimic的第三人称单数 );酷似
参考例句:
  • Methods:Models were generate by CT scan,Mimics software and Abaqus software. 方法:采用CT扫描,Mimics软件和Abaqus软件的CAD进行三维有限元模型的创建。 来自互联网
  • Relaxing the mind and body mimics the effect that some blood-pressure pills would have. 放松身心会产生某些降压药才能产生的效果。 来自辞典例句
9 pesticides abb0488ed6905584ea91347395a890e8     
n.杀虫剂( pesticide的名词复数 );除害药物
参考例句:
  • vegetables grown without the use of pesticides 未用杀虫剂种植的蔬菜
  • There is a lot of concern over the amount of herbicides and pesticides used in farming. 人们对农业上灭草剂和杀虫剂的用量非常担忧。 来自《简明英汉词典》
10 activation 24eed33ee38027d124839f0fcdf6adcb     
n. 激活,催化作用
参考例句:
  • A computer controls the activation of an air bag.电脑控制着气囊的启动。
11 genes 01914f8eac35d7e14afa065217edd8c0     
n.基因( gene的名词复数 )
参考例句:
  • You have good genes from your parents, so you should live a long time. 你从父母那儿获得优良的基因,所以能够活得很长。 来自《简明英汉词典》
  • Differences will help to reveal the functions of the genes. 它们间的差异将会帮助我们揭开基因多种功能。 来自英汉非文学 - 生命科学 - 生物技术的世纪
12 molecular mE9xh     
adj.分子的;克分子的
参考例句:
  • The research will provide direct insight into molecular mechanisms.这项研究将使人能够直接地了解分子的机理。
  • For the pressure to become zero, molecular bombardment must cease.当压强趋近于零时,分子的碰撞就停止了。
13 proceedings Wk2zvX     
n.进程,过程,议程;诉讼(程序);公报
参考例句:
  • He was released on bail pending committal proceedings. 他交保获释正在候审。
  • to initiate legal proceedings against sb 对某人提起诉讼
14 secretion QDozG     
n.分泌
参考例句:
  • Is there much secretion from your eyes?你眼里的分泌物多吗?
  • In addition,excessive secretion of oil,water scarcity are also major factors.除此之外,油脂分泌过盛、缺水也都是主要因素。
15 postulated 28ea70fa3a37cd78c20423a907408aaa     
v.假定,假设( postulate的过去式和过去分词 )
参考例句:
  • They postulated a 500-year lifespan for a plastic container. 他们假定塑料容器的寿命为500年。
  • Freud postulated that we all have a death instinct as well as a life instinct. 弗洛伊德曾假定我们所有人都有生存本能和死亡本能。 来自辞典例句
16 remains 1kMzTy     
n.剩余物,残留物;遗体,遗迹
参考例句:
  • He ate the remains of food hungrily.他狼吞虎咽地吃剩余的食物。
  • The remains of the meal were fed to the dog.残羹剩饭喂狗了。
17 activated c3905c37f4127686d512a7665206852e     
adj. 激活的 动词activate的过去式和过去分词
参考例句:
  • The canister is filled with activated charcoal.蒸气回收罐中充满了活性炭。
18 elucidating c3347aacbf818323096f8a40fa23e3d0     
v.阐明,解释( elucidate的现在分词 )
参考例句:
  • Our ancient music appearance-sprite theory attained the perfect state by his elucidating. 经过嵇康的阐发,我国古代音乐形神理论终臻完备。 来自互联网
  • Third, elucidating the vivid characters of Yangliuqing New Year Picture. 论述了杨柳青木版年画的鲜明的艺术风格。 来自互联网
19 binding 2yEzWb     
有约束力的,有效的,应遵守的
参考例句:
  • The contract was not signed and has no binding force. 合同没有签署因而没有约束力。
  • Both sides have agreed that the arbitration will be binding. 双方都赞同仲裁具有约束力。
20 genetic PgIxp     
adj.遗传的,遗传学的
参考例句:
  • It's very difficult to treat genetic diseases.遗传性疾病治疗起来很困难。
  • Each daughter cell can receive a full complement of the genetic information.每个子细胞可以收到遗传信息的一个完全补偿物。
21 mechanism zCWxr     
n.机械装置;机构,结构
参考例句:
  • The bones and muscles are parts of the mechanism of the body.骨骼和肌肉是人体的组成部件。
  • The mechanism of the machine is very complicated.这台机器的结构是非常复杂的。
22 mediating 85fbabf1ff334727095ecaab5335d0b6     
调停,调解,斡旋( mediate的现在分词 ); 居间促成; 影响…的发生; 使…可能发生
参考例句:
  • So many factors are mediating. 如此众多的因素在起作用。
  • The contrast in mediating noted in the sitting room. 客厅中注重了调和中的对比。
23 molting db85f1af31319318d646efa2505487ca     
n.蜕皮v.换羽,脱毛( molt的现在分词 )
参考例句:
  • The old cuticle is digested by molting fluid. 旧表皮被蜕皮液消化。 来自辞典例句
  • Molting in insects is triggered by rising levels of a hormone called ecdysone. 昆虫的脱皮是由于称为脱皮素激素的含量升高而引起的。 来自辞典例句
24 collaborating bd93aed5558c4b146fa553d822f7c432     
合作( collaborate的现在分词 ); 勾结叛国
参考例句:
  • Joe is collaborating on the work with a friend. 乔正与一位朋友合作做那件工作。
  • He was not only learning from but also collaborating with Joseph Thomson. 他不仅是在跟约瑟福?汤姆逊学习,而且也是在和他合作。
25 analyze RwUzm     
vt.分析,解析 (=analyse)
参考例句:
  • We should analyze the cause and effect of this event.我们应该分析这场事变的因果。
  • The teacher tried to analyze the cause of our failure.老师设法分析我们失败的原因。
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