Although recent evidence suggests that the clinical benefit may be uncertain for fibrates, a class of drugs used for the treatment of high lipid levels, use of these drugs is common in the U.S. and Canada, with usage increasing steadily¹ in the last decade in the U.S., especially for a brand-name fibrate product, according to a study in the March 23/30 issue of JAMA. Two studies in the last 5 years that included the use of fenofibrate failed to show a benefit in reducing cardiovascular（心血管的） events. "These negative studies raise questions about a medication with more than $1 billion in sales in the United States," according to background information in the study. "The main evidence for clinical benefit comes from placebo-controlled trials with the older fibrates such as gemfibrozil (for which some safety concerns were raised primarily when used with cerivastatin) and clofibrate (which is no longer available due to safety concerns). These trials exert substantial influence in meta-analyses that show that fibrates in aggregate² significantly reduce cardiac events but not overall mortality. The relevance³ of this older evidence to contemporary practice is uncertain, particularly given that the only trial to assess fibrates in a population taking statins yielded negative results." Little is known about how fibrates are used in practice.

Cynthia A. Jackevicius, Pharm.D., M.Sc., of Western University of Health Sciences, Pomona, Calif., and colleagues examined trends in the current use of fibrates in the United States and Canada. The study included data from the United States and Canada of patients prescribed fibrates between January 2002 and December 2009, and expenditures⁴（开支） associated with those prescriptions⁵.

In the United States, fibrate prescriptions dispensed⁶ increased from 336 prescriptions/100,000 population in January 2002 to 730 prescriptions/100,000 population in December 2009, an increase of 117.1 percent. In Canada, fibrate prescriptions increased from 402 prescriptions/100,000 population in January 2002 to 474 prescriptions/100,000 population in December 2009, an increase of 18.1 percent.

In the United States, fenofibrate prescriptions dispensed increased from 150 prescriptions/100,000 population in January 2002 to 440 prescriptions/100,000 population in December 2009. In Canada, fenofibrate prescriptions increased from 321 prescriptions/100,000 population in January 2002 to 429 prescriptions/100,000 population in December 2009. "Estimated fenofibrate use was relatively⁷ constant between 2002 and 2009 in Canada, while in the United States, use increased by 159.3 percent," the authors write.

In the United States, crude fenofibrate costs increased from $11,535/100,000 population/month in 2002 to $44,975/100,000 population/month in 2009, while in Canada, the costs declined for fenofibrate from $17,695/100,000 population/month in 2002 to $16,112/100,000 population/month in 2009. Adjusted estimated fibrate expenditures per 100,000 population were approximately 3-fold higher in 2009 in the United States compared with Canada.

The researchers also found that there was a strong preference observed for prescribing brand-name over generic⁸ fenofibrate products in the United States, but not in Canada.

"Access differences to generic fenofibrate between the United States and Canada likely contributed to the vastly different patterns of fenofibrate use, and are associated with a great economic burden for U.S. consumers and third-party payers," the authors write.

"Fibrates are used commonly in the United States and Canada. Use has increased steadily in the United States over the last decade despite published negative results from fibrate trials in patients with diabetes⁹ who were also taking statins（他汀类药物） ; however, fibrate use in Canada has remained stable. Fenofibrate dominates the market despite it having the least supportive clinical outcomes evidence. While this growth in the setting of a strong preference for brand-name over generic fenofibrate in the United States has been associated with higher medication costs, improvement in clinical outcomes is uncertain."