肾癌药物特癌适对间皮瘤有效
文章来源:未知 文章作者:enread 发布时间:2011-05-02 01:56 字体: [ ]  进入论坛
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A drug commonly used to treat kidney cancer may increase the effectiveness of chemotherapy(化学疗法) for mesothelioma(间皮瘤) , according to a study published in the May issue of the Journal of Thoracic Oncology. Temsirolimus, a kinase(激酶) inhibitor, blocks the action of mammalian target of rapamycin(雷帕霉素) (mTOR), a protein that regulates cell growth, which can slow tumor1 growth. It's used to treat advanced renal cell carcinoma.

But researchers in Austria have found that temsirolimus also may slow the growth of malignant2 pleural mesothelioma cells. Mesothelioma, a cancer that is usually caused by exposure to asbestos and may not appear until 30 to 50 years after exposure, frequently resists chemotherapy and radiation treatment.

The researchers found that temsirolimus strongly blocked mTOR-mediated signals and had a cytostatic, or growth-stopping, effect on all mesothelioma cells. However, mesothelioma cells that were resistant3 to cisplatin(铂化合物) , a widely used chemotherapy drug, showed hypersensitivity against temsirolimus.

That suggests that mTOR inhibitors like temsirolimus might be a promising4 treatment strategy either in combination with chemotherapy or as second-line treatment after chemotherapy failure.

"Malignant mesothelioma is a severe human malignancy characterized by a very bad prognosis, with a mean patient survival time of less than one year," said Professor Walter Berger, PhD, of the Institute of Cancer Research at the Medical University of Vienna. "This unacceptable situation is mainly caused by late diagnosis5 combined with a distinct resistance to all forms of systemic therapy available so far. Mesothelioma is frequently caused by asbestos(石棉) exposure and unfortunately -- based on the long latency period -- the incidence peak lies, despite the ban on asbestos, still ahead. Consequently, novel therapeutic6 options for this devastative disease are urgently needed.

"In our preclinical study, published in the JTO, we were able to demonstrate that inhibition of the major oncogene(致癌基因) mTOR is active against human mesothelioma especially after development of chemotherapy resistance both in vitro and in vivo," Berger said. "These results suggest the initiation7 of clinical trials involving mTOR inhibitors as a novel anti-mesothelioma strategy."



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1 tumor fKxzm     
n.(肿)瘤,肿块(英)tumour
参考例句:
  • He was died of a malignant tumor.他死于恶性肿瘤。
  • The surgeons irradiated the tumor.外科医生用X射线照射那个肿瘤。
2 malignant Z89zY     
adj.恶性的,致命的;恶意的,恶毒的
参考例句:
  • Alexander got a malignant slander.亚历山大受到恶意的诽谤。
  • He started to his feet with a malignant glance at Winston.他爬了起来,不高兴地看了温斯顿一眼。
3 resistant 7Wvxh     
adj.(to)抵抗的,有抵抗力的
参考例句:
  • Many pests are resistant to the insecticide.许多害虫对这种杀虫剂有抵抗力。
  • They imposed their government by force on the resistant population.他们以武力把自己的统治强加在持反抗态度的人民头上。
4 promising BkQzsk     
adj.有希望的,有前途的
参考例句:
  • The results of the experiments are very promising.实验的结果充满了希望。
  • We're trying to bring along one or two promising young swimmers.我们正设法培养出一两名有前途的年轻游泳选手。
5 diagnosis GvPxC     
n.诊断,诊断结果,调查分析,判断
参考例句:
  • His symptoms gave no obvious pointer to a possible diagnosis.他的症状无法作出明确的诊断。
  • The engineer made a complete diagnosis of the bridge's collapse.工程师对桥的倒塌做一次彻底的调查分析。
6 therapeutic sI8zL     
adj.治疗的,起治疗作用的;对身心健康有益的
参考例句:
  • Therapeutic measures were selected to fit the patient.选择治疗措施以适应病人的需要。
  • When I was sad,music had a therapeutic effect.我悲伤的时候,音乐有治疗效力。
7 initiation oqSzAI     
n.开始
参考例句:
  • her initiation into the world of marketing 她的初次涉足营销界
  • It was my initiation into the world of high fashion. 这是我初次涉足高级时装界。
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