艾滋病疫苗有望问世
文章来源:未知 文章作者:enread 发布时间:2011-05-08 06:05 字体: [ ]  进入论坛
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Latest insights into immunity1 to HIV could help to develop a vaccine2 to build antibodies' defences against the disease, a University of Melbourne, Australia study has found. By investigating the action of the human antibodies called ADCC, in people with HIV, researchers were able to identify that the virus evolves to evade3 or 'escape' the antibodies.

Professor Stephen Kent of the University of Melbourne and one of the senior authors on the paper said ADCC antibodies have been strongly implicated4 in protection from HIV in several vaccine trials but their action was poorly understood.

"These results show what a slippery customer the HIV virus is, but also shows that these ADCC antibodies are really forcing the virus into changing, in ways that cause it to be weaker," he said.

"It also implies that if good ADCC antibodies were available prior to infection, via a vaccine, we might be able to stop the virus taking hold. This is the holy grail."

The group at the University of Melbourne's Department of Microbiology and Immunology analysed blood samples of people with HIV and found their virus had evolved to evade or 'escape' the ADCC antibodies against HIV they are making to try to control their virus.

The team led by Dr Ivan Stratov and Professor Kent employed a novel technology developed in their laboratory to find where ADCC antibodies were attacking the virus. They then looked at how the sequence of the virus had mutated over time to avoid the immune response.

"There is an urgent need to identify effective immunity to HIV and our studies suggest ADCC responses supply significant immune pressure on the virus," Dr Ivan Stratov, a clinician and researcher said.

The group is now working on designing HIV vaccines5 to induce ADCC antibodies that make it more difficult for the virus to escape.

The work was published in the prestigious6 international journal PNAS(美国科学院院报).

 



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1 immunity dygyQ     
n.优惠;免除;豁免,豁免权
参考例句:
  • The law gives public schools immunity from taxation.法律免除公立学校的纳税义务。
  • He claims diplomatic immunity to avoid being arrested.他要求外交豁免以便避免被捕。
2 vaccine Ki1wv     
n.牛痘苗,疫苗;adj.牛痘的,疫苗的
参考例句:
  • The polio vaccine has saved millions of lives.脊髓灰质炎疫苗挽救了数以百万计的生命。
  • She takes a vaccine against influenza every fall.她每年秋季接种流感疫苗。
3 evade evade     
vt.逃避,回避;避开,躲避
参考例句:
  • He tried to evade the embarrassing question.他企图回避这令人难堪的问题。
  • You are in charge of the job.How could you evade the issue?你是负责人,你怎么能对这个问题不置可否?
4 implicated 8443a53107b44913ed0a3f12cadfa423     
adj.密切关联的;牵涉其中的
参考例句:
  • These groups are very strongly implicated in the violence. 这些组织与这起暴力事件有着极大的关联。 来自《简明英汉词典》
  • Having the stolen goods in his possession implicated him in the robbery. 因藏有赃物使他涉有偷盗的嫌疑。 来自《现代汉英综合大词典》
5 vaccines c9bb57973a82c1e95c7cd0f4988a1ded     
疫苗,痘苗( vaccine的名词复数 )
参考例句:
  • His team are at the forefront of scientific research into vaccines. 他的小组处于疫苗科研的最前沿。
  • The vaccines were kept cool in refrigerators. 疫苗放在冰箱中冷藏。
6 prestigious nQ2xn     
adj.有威望的,有声望的,受尊敬的
参考例句:
  • The young man graduated from a prestigious university.这个年轻人毕业于一所名牌大学。
  • You may even join a prestigious magazine as a contributing editor.甚至可能会加入一个知名杂志做编辑。
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