合并抗体疗法对转移性黑色素瘤有疗效
文章来源:未知 文章作者:enread 发布时间:2011-06-05 03:16 字体: [ ]  进入论坛
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A duo of drugs, each targeting a prime survival strategy of tumors, can be safely administered and are potentially more effective than either drug alone for advanced, inoperable melanomas(黑素瘤) , according to a phase 1 clinical trial led by Dana-Farber Cancer Institute investigators2. The findings (abstract 8511), will be presented in an oral session at the annual meeting of the American Society of Clinical Oncology on Saturday, June 4, 3 p.m. CT, Arie Crown Theater, McCormick Place.

The drugs -- ipilimumab and bevacizumab -- are both monoclonal antibodies, intensified3 formulations of natural disease-fighting proteins. Ipilimumab spurs the immune system to attack diseased cells, including tumor1 cells. Bevacizumab, also known by the trade name Avastin, blocks the growth of blood vessels4 that provide tumors with nourishment5. Ipilimumab has extended the lives of metastatic melanoma patients in previous clinical trials, and bevacizumab is often used to treat tumors of the colon6, lung, and kidney.

The trial involved 22 patients with metatastic melanoma that was not treatable by surgery.

F. Stephen Hodi, MD, the study's lead author and director of the melanoma treatment center at Dana-Farber, said the trial is the first to explore whether the two agents enhance each other's effectiveness. Most of the participants didn't experience serious adverse7 side effects, although some did experience inflammation of artery8 walls, the liver, thyroid gland9, colon, or uvea(葡萄膜) (the middle layer of the eye). Five patients required steroid treatment for these problems and were removed the trial.

Positron emission10 tomography (PET正电子成像术) scans showed a prompt immune system response to many of the melanoma tumors, and computed11 tomography (CT) scans showed decreased blood flow to the tumors. Eight of the participants had partial responses -- showing some tumor shrinkage -- to the dual12 treatment, and six had stable disease. All the responses lasted at least six months. Biopsies performed after the treatment showed a more vigorous immune system response than would be expected with ipilimumab alone.

"Our findings indicate that ipilimumab and bevacizumab can be safely administered with careful management of side effects," said Hodi. "The results of lab tests suggest that the two agents may work synergistically(协同地) , with 14 of 21 evaluable patients experiencing a clinical benefit. This approach merits exploration in further clinical trials."



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1 tumor fKxzm     
n.(肿)瘤,肿块(英)tumour
参考例句:
  • He was died of a malignant tumor.他死于恶性肿瘤。
  • The surgeons irradiated the tumor.外科医生用X射线照射那个肿瘤。
2 investigators e970f9140785518a87fc81641b7c89f7     
n.调查者,审查者( investigator的名词复数 )
参考例句:
  • This memo could be the smoking gun that investigators have been looking for. 这份备忘录可能是调查人员一直在寻找的证据。
  • The team consisted of six investigators and two secretaries. 这个团队由六个调查人员和两个秘书组成。 来自《简明英汉词典》
3 intensified 4b3b31dab91d010ec3f02bff8b189d1a     
v.(使)增强, (使)加剧( intensify的过去式和过去分词 )
参考例句:
  • Violence intensified during the night. 在夜间暴力活动加剧了。
  • The drought has intensified. 旱情加剧了。 来自《简明英汉词典》
4 vessels fc9307c2593b522954eadb3ee6c57480     
n.血管( vessel的名词复数 );船;容器;(具有特殊品质或接受特殊品质的)人
参考例句:
  • The river is navigable by vessels of up to 90 tons. 90 吨以下的船只可以从这条河通过。 来自《简明英汉词典》
  • All modern vessels of any size are fitted with radar installations. 所有现代化船只都有雷达装置。 来自《现代汉英综合大词典》
5 nourishment Ovvyi     
n.食物,营养品;营养情况
参考例句:
  • Lack of proper nourishment reduces their power to resist disease.营养不良降低了他们抵抗疾病的能力。
  • He ventured that plants draw part of their nourishment from the air.他大胆提出植物从空气中吸收部分养分的观点。
6 colon jqfzJ     
n.冒号,结肠,直肠
参考例句:
  • Here,too,the colon must be followed by a dash.这里也是一样,应当在冒号后加破折号。
  • The colon is the locus of a large concentration of bacteria.结肠是大浓度的细菌所在地。
7 adverse 5xBzs     
adj.不利的;有害的;敌对的,不友好的
参考例句:
  • He is adverse to going abroad.他反对出国。
  • The improper use of medicine could lead to severe adverse reactions.用药不当会产生严重的不良反应。
8 artery 5ekyE     
n.干线,要道;动脉
参考例句:
  • We couldn't feel the changes in the blood pressure within the artery.我们无法感觉到动脉血管内血压的变化。
  • The aorta is the largest artery in the body.主动脉是人体中的最大动脉。
9 gland qeGzu     
n.腺体,(机)密封压盖,填料盖
参考例句:
  • This is a snake's poison gland.这就是蛇的毒腺。
  • Her mother has an underactive adrenal gland.她的母亲肾上腺机能不全。
10 emission vjnz4     
n.发出物,散发物;发出,散发
参考例句:
  • Rigorous measures will be taken to reduce the total pollutant emission.采取严格有力措施,降低污染物排放总量。
  • Finally,the way to effectively control particulate emission is pointed out.最后,指出有效降低颗粒排放的方向。
11 computed 5a317d3dd3f7a2f675975a6d0c11c629     
adj.[医]计算的,使用计算机的v.计算,估算( compute的过去式和过去分词 )
参考例句:
  • He computed that the project would take seven years to complete. 他估计这项计划要花七年才能完成。 来自《简明英汉词典》
  • Resolving kernels and standard errors can also be computed for each block. 还可以计算每个块体的分辨核和标准误差。 来自辞典例句
12 dual QrAxe     
adj.双的;二重的,二元的
参考例句:
  • The people's Republic of China does not recognize dual nationality for any Chinese national.中华人民共和国不承认中国公民具有双重国籍。
  • He has dual role as composer and conductor.他兼作曲家及指挥的双重身分。
TAG标签: drugs tumors melanomas
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