某化合物或可治疗亨廷顿舞蹈症
文章来源:未知 文章作者:enread 发布时间:2011-06-24 05:06 字体: [ ]  进入论坛
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UT Southwestern Medical Center researchers have identified compounds that appear to inhibit1(抑制) a signaling pathway in Huntington's disease, a finding that may eventually lead to a potential drug therapy to help slow the progression of degenerative nerve disorders3. "Our studies have uncovered a new therapeutic4 target for Huntington's disease treatment and possibly for other neurodegenerative diseases," said Dr. Ilya Bezprozvanny, professor of physiology5 and senior author of the study, published in today's issue of Chemistry and Biology. "In addition, we now have this new series of compounds that gives us a tool to study the pathogenesis(发病机理) of Huntington's disease."

Huntington's disease is a fatal genetic6 disorder2 in which certain brain cells waste away. More than 250,000 people in the U.S. have the disorder or are at risk for it. The most common form is adult-onset7, with symptoms usually developing in patients in their mid-30s and 40s.

The disease results in uncontrolled movements, psychiatric(精神病学的) disturbance8, gradual dementia and eventually death. There is no therapy available currently to slow the progression of the disease.

Scientists at UT Southwestern found that quinazoline-derived compounds effectively block what is known as the store-operated calcium9 entry signaling pathway, which was never before implicated10 in Huntington nerve cells but that might be a therapeutic target in the disease.

Dr. Bezprozvanny's laboratory research has contributed to growing scientific evidence that suggests abnormalities in neuronal calcium signaling play an important role in the development of Huntington's disease. UT Southwestern researchers demonstrated in the current study that the quinoline(喹啉) compounds – supplied by EnVivo – protected brain cells.

"If this holds, this compound can be considered to have potential therapeutic application for Huntington's," he said. "As we ultimately seek a cure, we are encouraged to have found something that may slow the progress or delay the onset of the disease."



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1 inhibit C7jxT     
vt.阻止,妨碍,抑制
参考例句:
  • Don't let ego and greed inhibit clear thinking and hard work.不要让自我和贪婪妨碍清晰的思维和刻苦的工作。
  • They passed a law to inhibit people from parking in the street.他们通过一项法令以阻止人们在街上停车。
2 disorder Et1x4     
n.紊乱,混乱;骚动,骚乱;疾病,失调
参考例句:
  • When returning back,he discovered the room to be in disorder.回家后,他发现屋子里乱七八糟。
  • It contained a vast number of letters in great disorder.里面七零八落地装着许多信件。
3 disorders 6e49dcafe3638183c823d3aa5b12b010     
n.混乱( disorder的名词复数 );凌乱;骚乱;(身心、机能)失调
参考例句:
  • Reports of anorexia and other eating disorders are on the increase. 据报告,厌食症和其他饮食方面的功能紊乱发生率正在不断增长。 来自《简明英汉词典》
  • The announcement led to violent civil disorders. 这项宣布引起剧烈的骚乱。 来自《简明英汉词典》
4 therapeutic sI8zL     
adj.治疗的,起治疗作用的;对身心健康有益的
参考例句:
  • Therapeutic measures were selected to fit the patient.选择治疗措施以适应病人的需要。
  • When I was sad,music had a therapeutic effect.我悲伤的时候,音乐有治疗效力。
5 physiology uAfyL     
n.生理学,生理机能
参考例句:
  • He bought a book about physiology.他买了一本生理学方面的书。
  • He was awarded the Nobel Prize for achievements in physiology.他因生理学方面的建树而被授予诺贝尔奖。
6 genetic PgIxp     
adj.遗传的,遗传学的
参考例句:
  • It's very difficult to treat genetic diseases.遗传性疾病治疗起来很困难。
  • Each daughter cell can receive a full complement of the genetic information.每个子细胞可以收到遗传信息的一个完全补偿物。
7 onset bICxF     
n.进攻,袭击,开始,突然开始
参考例句:
  • The drug must be taken from the onset of the infection.这种药必须在感染的最初期就开始服用。
  • Our troops withstood the onset of the enemy.我们的部队抵挡住了敌人的进攻。
8 disturbance BsNxk     
n.动乱,骚动;打扰,干扰;(身心)失调
参考例句:
  • He is suffering an emotional disturbance.他的情绪受到了困扰。
  • You can work in here without any disturbance.在这儿你可不受任何干扰地工作。
9 calcium sNdzY     
n.钙(化学符号Ca)
参考例句:
  • We need calcium to make bones.我们需要钙来壮骨。
  • Calcium is found most abundantly in milk.奶含钙最丰富。
10 implicated 8443a53107b44913ed0a3f12cadfa423     
adj.密切关联的;牵涉其中的
参考例句:
  • These groups are very strongly implicated in the violence. 这些组织与这起暴力事件有着极大的关联。 来自《简明英汉词典》
  • Having the stolen goods in his possession implicated him in the robbery. 因藏有赃物使他涉有偷盗的嫌疑。 来自《现代汉英综合大词典》
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