猪干细胞研究获得有益启示
文章来源:未知 文章作者:enread 发布时间:2011-12-11 03:46 字体: [ ]  进入论坛
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Pig stem cell research conducted by two animal scientists at the University of Georgia reveals a better way to determine the safety of future stem cell therapies than rodent1-based models. Rodent studies are likely inadequate2 for testing many human therapies -- including pharmaceuticals3 -- since 50 percent of all chemicals test positive as carcinogens in rodents4 regardless of their source or identity, according to Thomas Hartung, a professor in the Bloomsburg College of Public Health at Johns Hopkins University. He suggests these rodent studies may be no better than a coin toss. For example, some components5 in coffee appear to be carcinogenic in rodents, but in humans moderate coffee consumption may reduce the risk of cancer.

In 2010, UGA faculty6 Steve Stice and Franklin West introduced 13 pigs that have shown promise in unlocking the path to new therapies. The pigs recently produced another positive finding: These adult-cell-sourced stem cells don't form tumors in pigs.

"Pluripotent(多能的) stem cells have significant potential for stem cell therapies," said West, an animal science researcher and assistant professor in the UGA College of Agricultural and Environmental Sciences. "However, tests in mice often resulted in tumor7 formation that frequently led to death."

The formation of tumors has raised concerns about the safety of induced pluripotent stem cells, or iPSCs, and cells derived8 from these stem cells. Until now, all iPSC safety studies have been performed in rodent(啮齿动物) models.

"To address the concern, our research team studied tumor formation in pigs generated from pig iPSCs," West said. "Brain, skin, liver, pancreas(胰腺) , stomach, intestine9(肠) , lung, heart, kidney, muscle, spleen(脾脏) and gonad(性腺) tissues from all 11 pigs tested showed no evidence of tumors."

The absence of tumor formation in these pigs suggests that iPSCs can safely incorporate into tissues without tumor formation.

"Being able to safely use iPSCs without the potential of causing tumors is essential for this promising10 stem cell therapy to become a viable11 treatment option," said Stice, a Georgia Research Alliance Eminent12 Scholar in the College of Agricultural and Environmental Sciences. "We now have graduate students working on making neural13(神经的) cells from the human and pig stem cells to help further the studies. The human stem cells were effective in a rodent model for stroke, but rodent studies are not rigorous enough to start human clinical trials."

West agrees. "Over 700 drug treatments have gone to human clinical trials for stroke alone based on findings in rodents and have turned out not to be viable in humans," he said. "The pigs are much more human like, and they are going to be a much better model to study strokes."a



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1 rodent DsNyh     
n.啮齿动物;adj.啮齿目的
参考例句:
  • When there is a full moon,this nocturnal rodent is careful to stay in its burrow.月圆之夜,这种夜间活动的啮齿类动物会小心地呆在地洞里不出来。
  • This small rodent can scoop out a long,narrow tunnel in a very short time.这种小啮齿动物能在很短的时间里挖出一条又长又窄的地道来。
2 inadequate 2kzyk     
adj.(for,to)不充足的,不适当的
参考例句:
  • The supply is inadequate to meet the demand.供不应求。
  • She was inadequate to the demands that were made on her.她还无力满足对她提出的各项要求。
3 pharmaceuticals be065c8a4af3a2d925d11969faac34cf     
n.医药品;药物( pharmaceutical的名词复数 )
参考例句:
  • the development of new pharmaceuticals 新药的开发
  • The companies are pouring trillions of yen into biotechnology research,especially for pharmaceuticals and new seeds. 这些公司将大量资金投入生物工艺学研究,尤其是药品和新种子方面。 来自《简明英汉词典》
4 rodents 1ff5f0f12f2930e77fb620b1471a2124     
n.啮齿目动物( rodent的名词复数 )
参考例句:
  • Rodents carry diseases and are generally regarded as pests. 啮齿目动物传播疾病,常被当作害虫对待。 来自《简明英汉词典》
  • Some wild rodents in Africa also harbor the virus. 在非洲,有些野生啮齿动物也是储毒者。 来自辞典例句
5 components 4725dcf446a342f1473a8228e42dfa48     
(机器、设备等的)构成要素,零件,成分; 成分( component的名词复数 ); [物理化学]组分; [数学]分量; (混合物的)组成部分
参考例句:
  • the components of a machine 机器部件
  • Our chemistry teacher often reduces a compound to its components in lab. 在实验室中化学老师常把化合物分解为各种成分。
6 faculty HhkzK     
n.才能;学院,系;(学院或系的)全体教学人员
参考例句:
  • He has a great faculty for learning foreign languages.他有学习外语的天赋。
  • He has the faculty of saying the right thing at the right time.他有在恰当的时候说恰当的话的才智。
7 tumor fKxzm     
n.(肿)瘤,肿块(英)tumour
参考例句:
  • He was died of a malignant tumor.他死于恶性肿瘤。
  • The surgeons irradiated the tumor.外科医生用X射线照射那个肿瘤。
8 derived 6cddb7353e699051a384686b6b3ff1e2     
vi.起源;由来;衍生;导出v.得到( derive的过去式和过去分词 );(从…中)得到获得;源于;(从…中)提取
参考例句:
  • Many English words are derived from Latin and Greek. 英语很多词源出于拉丁文和希腊文。 来自《简明英汉词典》
  • He derived his enthusiasm for literature from his father. 他对文学的爱好是受他父亲的影响。 来自《简明英汉词典》
9 intestine rbpzY     
adj.内部的;国内的;n.肠
参考例句:
  • This vitamin is absorbed through the walls of the small intestine.这种维生素通过小肠壁被吸收。
  • The service productivity is the function,including external efficiency,intestine efficiency and capacity efficiency.服务业的生产率是一个包含有外部效率、内部效率和能力效率的函数。
10 promising BkQzsk     
adj.有希望的,有前途的
参考例句:
  • The results of the experiments are very promising.实验的结果充满了希望。
  • We're trying to bring along one or two promising young swimmers.我们正设法培养出一两名有前途的年轻游泳选手。
11 viable mi2wZ     
adj.可行的,切实可行的,能活下去的
参考例句:
  • The scheme is economically viable.这个计划从经济效益来看是可行的。
  • The economy of the country is not viable.这个国家经济是难以维持的。
12 eminent dpRxn     
adj.显赫的,杰出的,有名的,优良的
参考例句:
  • We are expecting the arrival of an eminent scientist.我们正期待一位著名科学家的来访。
  • He is an eminent citizen of China.他是一个杰出的中国公民。
13 neural DnXzFt     
adj.神经的,神经系统的
参考例句:
  • The neural network can preferably solve the non- linear problem.利用神经网络建模可以较好地解决非线性问题。
  • The information transmission in neural system depends on neurotransmitters.信息传递的神经途径有赖于神经递质。
TAG标签: pig stem cell
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