长期睾酮治疗可使男性体重腰围下降
文章来源:未知 文章作者:enread 发布时间:2012-06-26 05:44 字体: [ ]  进入论坛
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In testosterone(睾丸素) -deficient men, major weight loss was an added benefit of testosterone replacement1 therapy for most of the patients who participated in a new study. The results will be presented June 23 at The Endocrine Society's 94th Annual Meeting in Houston.

"The substantial weight loss found in our study -- an average of 36 pounds -- was a surprise," said the study's lead author, Farid Saad, PhD, of Berlin-headquartered Bayer Pharma.

Although prior studies using testosterone therapy in testosterone-deficient men consistently show changes in body composition, such as increased lean mass and decreased fat mass, Saad said the net effect on weight seemed unchanged in those studies. However, Saad said their study, which took place in Germany, had a longer follow-up by at least two years and used long-acting injections of testosterone.

The investigators2 restored testosterone to normal levels in 255 testosterone-deficient ("hypogonadal") men, whose average age was nearly 61 (range, 38 to 83 years). Treatment lasted for up to five years, with injections given at day 1, after 6 weeks and then every 12 weeks after that. Patients did not follow a controlled diet or standard exercise program but received advice to improve their lifestyle habits.

On average, the men weighed 236 pounds before beginning testosterone treatment and 200 pounds after treatment (106.2 versus3 90 kilograms), the authors reported. Weight loss was reportedly continuous, with an average reduction in body weight ranging from about 4 percent after one year of treatment to more than 13 percent after five years.

In addition, men lost an average of nearly 3.5 inches (8.8 centimeters) around their waist.

"These results are encouraging because studies show that weight loss drugs and lifestyle interventions4 have been largely unsuccessful, especially long term," Saad said.

Testosterone deficiency becomes more common with age. Saad said many middle-aged5 men with testosterone deficiency are obese6, explaining that there is "a vicious(恶毒的) circle" in obesity7 and low testosterone.

"Obesity is associated with reduced testosterone, and low testosterone induces weight gain," Saad wrote in the study abstract.

Testosterone replacement is the standard treatment for most men with symptomatic testosterone deficiency, according to The Endocrine Society guidelines.

In the study by Saad and colleagues, treatment used a slow-release, injectable form of the male hormone8 (testosterone undecanoate) that is not yet available in the United States. It is marketed in Europe, Latin America, Australia and parts of Asia and Africa.

Saad is an employee of Bayer Pharma, which makes a brand of testosterone undecanoate and which partially9 funded the study in its final two years.



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1 replacement UVxxM     
n.取代,替换,交换;替代品,代用品
参考例句:
  • We are hard put to find a replacement for our assistant.我们很难找到一个人来代替我们的助手。
  • They put all the students through the replacement examination.他们让所有的学生参加分班考试。
2 investigators e970f9140785518a87fc81641b7c89f7     
n.调查者,审查者( investigator的名词复数 )
参考例句:
  • This memo could be the smoking gun that investigators have been looking for. 这份备忘录可能是调查人员一直在寻找的证据。
  • The team consisted of six investigators and two secretaries. 这个团队由六个调查人员和两个秘书组成。 来自《简明英汉词典》
3 versus wi7wU     
prep.以…为对手,对;与…相比之下
参考例句:
  • The big match tonight is England versus Spain.今晚的大赛是英格兰对西班牙。
  • The most exciting game was Harvard versus Yale.最富紧张刺激的球赛是哈佛队对耶鲁队。
4 interventions b4e9b73905db5b0213891229ce84fdd3     
n.介入,干涉,干预( intervention的名词复数 )
参考例句:
  • Economic analysis of government interventions deserves detailed discussion. 政府对经济的干预应该给予充分的论述。 来自辞典例句
  • The judge's frequent interventions made a mockery of justice. 法官的屡屡干预是对正义的践踏。 来自互联网
5 middle-aged UopzSS     
adj.中年的
参考例句:
  • I noticed two middle-aged passengers.我注意到两个中年乘客。
  • The new skin balm was welcome by middle-aged women.这种新护肤香膏受到了中年妇女的欢迎。
6 obese uvIya     
adj.过度肥胖的,肥大的
参考例句:
  • The old man is really obese,it can't be healthy.那位老人确实过于肥胖了,不能算是健康。
  • Being obese and lazy is dangerous to health.又胖又懒危害健康。
7 obesity Dv1ya     
n.肥胖,肥大
参考例句:
  • One effect of overeating may be obesity.吃得过多能导致肥胖。
  • Sugar and fat can more easily lead to obesity than some other foods.糖和脂肪比其他食物更容易导致肥胖。
8 hormone uyky3     
n.荷尔蒙,激素,内分泌
参考例句:
  • Hormone implants are used as growth boosters.激素植入物被用作生长辅助剂。
  • This hormone interacts closely with other hormones in the body.这种荷尔蒙与体內其他荷尔蒙紧密地相互作用。
9 partially yL7xm     
adv.部分地,从某些方面讲
参考例句:
  • The door was partially concealed by the drapes.门有一部分被门帘遮住了。
  • The police managed to restore calm and the curfew was partially lifted.警方设法恢复了平静,宵禁部分解除。
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