肥胖时间越久 体重越难下降
文章来源:未知 文章作者:enread 发布时间:2012-10-25 06:00 字体: [ ]  进入论坛
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Joint1 research between the University of Michigan and the Argentina-based National Council of Science and Technology (CONICET) has shed light on one of the most frustrating2 mysteries of weight loss -- why the weight inevitably3 comes back. A novel animal model showed that the longer mice remained overweight, the more "irreversible" obesity4 became, according to the new study that appeared online ahead of print Oct.24 in the Journal of Clinical Investigation5.
 
Over time, the static(静态的), obese6 state of the mice reset7 the "normal," body weight set point to become permanently8 elevated, despite dieting that initially9 worked to shed pounds, authors say.
 
"Our model demonstrates that obesity is in part a self-perpetuating disorder10 and the results further emphasize the importance of early intervention11 in childhood to try to prevent the condition whose effects can last a lifetime," says senior author Malcolm J. Low, M.D., Ph.D., professor of molecular12 and integrative(综合的) physiology13 and internal medicine.
 
"Our new animal model will be useful in pinpointing14 the reasons why most adults find it exceedingly difficult to maintain meaningful weight loss from dieting and exercise alone."
 
The lead author of the study was Viviana F. Bumaschny, M.D., assistant investigator15 of CONICET.
 
Obesity affects more than 500 million adults and 43 million children younger than age 5, while related illnesses are the leading preventable cause of death.
 
Individuals who are overweight have a much higher risk of type 2 diabetes16, hypertension, and cardiovascular diseases.
 
One of the major strengths of the research was a new model of obesity-programmed mice that allowed weight loss success to be tracked at different stages and ages by flipping18 a genetic19 switch that controls hunger.
 
Turning on the switch right after weaning prevented the mice from overeating and ever becoming obese. Similarly, mice that remained at a healthy weight into young adulthood20 by strict dieting alone were able to maintain normal weight without dieting after turning on the switch. However, chronically21 overfed mice with the earliest onset22 of obesity never completely returned to normal weight after flipping the switch, despite marked reduction in food intake23 and increased activity.
 
The new findings may raise questions about the long-term success rate of severe calorie restriction24 and strenuous25 exercise used later in life to lose weight, such as the extreme regimens seen in the popular reality television show "Biggest Loser."
 
"Somewhere along the way, if obesity is allowed to continue, the body appears to flip17 a switch that re-programs to a heavier set weight," Low says. "The exact mechanisms26 that cause this shift are still unknown and require much further study that will help us better understand why the regaining27 of weight seems almost unavoidable."
 
The findings will be published alongside a corresponding commentary "Tipping the scales early: probing the long-term effects of obesity."


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1 joint m3lx4     
adj.联合的,共同的;n.关节,接合处;v.连接,贴合
参考例句:
  • I had a bad fall,which put my shoulder out of joint.我重重地摔了一跤,肩膀脫臼了。
  • We wrote a letter in joint names.我们联名写了封信。
2 frustrating is9z54     
adj.产生挫折的,使人沮丧的,令人泄气的v.使不成功( frustrate的现在分词 );挫败;使受挫折;令人沮丧
参考例句:
  • It's frustrating to have to wait so long. 要等这么长时间,真令人懊恼。
  • It was a demeaning and ultimately frustrating experience. 那是一次有失颜面并且令人沮丧至极的经历。 来自《简明英汉词典》
3 inevitably x7axc     
adv.不可避免地;必然发生地
参考例句:
  • In the way you go on,you are inevitably coming apart.照你们这样下去,毫无疑问是会散伙的。
  • Technological changes will inevitably lead to unemployment.技术变革必然会导致失业。
4 obesity Dv1ya     
n.肥胖,肥大
参考例句:
  • One effect of overeating may be obesity.吃得过多能导致肥胖。
  • Sugar and fat can more easily lead to obesity than some other foods.糖和脂肪比其他食物更容易导致肥胖。
5 investigation MRKzq     
n.调查,调查研究
参考例句:
  • In an investigation,a new fact became known, which told against him.在调查中新发现了一件对他不利的事实。
  • He drew the conclusion by building on his own investigation.他根据自己的调查研究作出结论。
6 obese uvIya     
adj.过度肥胖的,肥大的
参考例句:
  • The old man is really obese,it can't be healthy.那位老人确实过于肥胖了,不能算是健康。
  • Being obese and lazy is dangerous to health.又胖又懒危害健康。
7 reset rkHzYJ     
v.重新安排,复位;n.重新放置;重放之物
参考例句:
  • As soon as you arrive at your destination,step out of the aircraft and reset your wristwatch.你一到达目的地,就走出飞机并重新设置手表时间。
  • He is recovering from an operation to reset his arm.他做了一个手臂复位手术,正在恢复。
8 permanently KluzuU     
adv.永恒地,永久地,固定不变地
参考例句:
  • The accident left him permanently scarred.那次事故给他留下了永久的伤疤。
  • The ship is now permanently moored on the Thames in London.该船现在永久地停泊在伦敦泰晤士河边。
9 initially 273xZ     
adv.最初,开始
参考例句:
  • The ban was initially opposed by the US.这一禁令首先遭到美国的反对。
  • Feathers initially developed from insect scales.羽毛最初由昆虫的翅瓣演化而来。
10 disorder Et1x4     
n.紊乱,混乱;骚动,骚乱;疾病,失调
参考例句:
  • When returning back,he discovered the room to be in disorder.回家后,他发现屋子里乱七八糟。
  • It contained a vast number of letters in great disorder.里面七零八落地装着许多信件。
11 intervention e5sxZ     
n.介入,干涉,干预
参考例句:
  • The government's intervention in this dispute will not help.政府对这场争论的干预不会起作用。
  • Many people felt he would be hostile to the idea of foreign intervention.许多人觉得他会反对外来干预。
12 molecular mE9xh     
adj.分子的;克分子的
参考例句:
  • The research will provide direct insight into molecular mechanisms.这项研究将使人能够直接地了解分子的机理。
  • For the pressure to become zero, molecular bombardment must cease.当压强趋近于零时,分子的碰撞就停止了。
13 physiology uAfyL     
n.生理学,生理机能
参考例句:
  • He bought a book about physiology.他买了一本生理学方面的书。
  • He was awarded the Nobel Prize for achievements in physiology.他因生理学方面的建树而被授予诺贝尔奖。
14 pinpointing 0feaf9de6fb06f40e50c160d8a3f811c     
准确地找出或描述( pinpoint的现在分词 ); 为…准确定位
参考例句:
  • The difficulty of pinpointing primitive and derived characters remains. 要正确地指出原始性状和次生性状仍然感到困难。
  • Pinpointing the true source of power in Japan is a notoriously slippery task. 要准确指出日本真正的权力来源,是一项非常困难的任务。
15 investigator zRQzo     
n.研究者,调查者,审查者
参考例句:
  • He was a special investigator for the FBI.他是联邦调查局的特别调查员。
  • The investigator was able to deduce the crime and find the criminal.调查者能够推出犯罪过程并锁定罪犯。
16 diabetes uPnzu     
n.糖尿病
参考例句:
  • In case of diabetes, physicians advise against the use of sugar.对于糖尿病患者,医生告诫他们不要吃糖。
  • Diabetes is caused by a fault in the insulin production of the body.糖尿病是由体內胰岛素分泌失调引起的。
17 flip Vjwx6     
vt.快速翻动;轻抛;轻拍;n.轻抛;adj.轻浮的
参考例句:
  • I had a quick flip through the book and it looked very interesting.我很快翻阅了一下那本书,看来似乎很有趣。
  • Let's flip a coin to see who pays the bill.咱们来抛硬币决定谁付钱。
18 flipping b69cb8e0c44ab7550c47eaf7c01557e4     
讨厌之极的
参考例句:
  • I hate this flipping hotel! 我讨厌这个该死的旅馆!
  • Don't go flipping your lid. 别发火。
19 genetic PgIxp     
adj.遗传的,遗传学的
参考例句:
  • It's very difficult to treat genetic diseases.遗传性疾病治疗起来很困难。
  • Each daughter cell can receive a full complement of the genetic information.每个子细胞可以收到遗传信息的一个完全补偿物。
20 adulthood vKsyr     
n.成年,成人期
参考例句:
  • Some infantile actions survive into adulthood.某些婴儿期的行为一直保持到成年期。
  • Few people nowadays are able to maintain friendships into adulthood.如今很少有人能将友谊维持到成年。
21 chronically yVsyi     
ad.长期地
参考例句:
  • Similarly, any pigment nevus that is chronically irritated should be excised. 同样,凡是经常受慢性刺激的各种色素痣切勿予以切除。
  • People chronically exposed to chlorine develop some degree of tolerance. 人长期接触氯气可以产生某种程度的耐受性。
22 onset bICxF     
n.进攻,袭击,开始,突然开始
参考例句:
  • The drug must be taken from the onset of the infection.这种药必须在感染的最初期就开始服用。
  • Our troops withstood the onset of the enemy.我们的部队抵挡住了敌人的进攻。
23 intake 44cyQ     
n.吸入,纳入;进气口,入口
参考例句:
  • Reduce your salt intake.减少盐的摄入量。
  • There was a horrified intake of breath from every child.所有的孩子都害怕地倒抽了一口凉气。
24 restriction jW8x0     
n.限制,约束
参考例句:
  • The park is open to the public without restriction.这个公园对公众开放,没有任何限制。
  • The 30 mph speed restriction applies in all built-up areas.每小时限速30英里适用于所有建筑物聚集区。
25 strenuous 8GvzN     
adj.奋发的,使劲的;紧张的;热烈的,狂热的
参考例句:
  • He made strenuous efforts to improve his reading. 他奋发努力提高阅读能力。
  • You may run yourself down in this strenuous week.你可能会在这紧张的一周透支掉自己。
26 mechanisms d0db71d70348ef1c49f05f59097917b8     
n.机械( mechanism的名词复数 );机械装置;[生物学] 机制;机械作用
参考例句:
  • The research will provide direct insight into molecular mechanisms. 这项研究将使人能够直接地了解分子的机理。 来自《简明英汉词典》
  • He explained how the two mechanisms worked. 他解释这两台机械装置是如何工作的。 来自《简明英汉词典》
27 regaining 458e5f36daee4821aec7d05bf0dd4829     
复得( regain的现在分词 ); 赢回; 重回; 复至某地
参考例句:
  • She was regaining consciousness now, but the fear was coming with her. 现在她正在恢发她的知觉,但是恐怖也就伴随着来了。
  • She said briefly, regaining her will with a click. 她干脆地答道,又马上重新振作起精神来。
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