Humans with a high motor excitability（兴奋性，应激性） have a better working memory than humans with a low excitability. This was shown in a study conducted by scientists from the Transfacultary Research Platform at the University of Basel. By measuring the motor excitability, conclusions can be drawn¹ as to the general cortical（皮质的） excitability -- as well as to cognitive² performance. Working memory allows the temporary storage of information such as memorizing a phone number for a short period of time. Studies in animals have shown that working memory processes among others depend on the excitability of neurons in the prefrontal cortex. Moreover, there is evidence that motor neuronal excitability might be related to the neuronal excitability of other cortical regions. Researchers from the Psychiatric University Clinics (UPK Basel) and the Faculty³ of Psychology⁴ in Basel have now studied if the excitability of the motor cortex correlates with working memory performance- results were positive.

 

"The motor cortical excitability can be easily studied with transcranial（经颅的） magnetic stimulation⁵," says Nathalie Schicktanz, doctoral student and first author of the study. During this procedure, electromagnetic impulses with increasing intensity⁶ are applied⁷ over the motor cortex. For subjects with high motor excitability already weak impulses are sufficient to trigger certain muscles -- such as those of the hand -- to show a visible twitch⁸.

 

 

In the present study, that included 188 healthy young subjects, the scientists were able to show that subjects with a high motor excitability had increased working memory performance as compared to subjects with a low excitability. "By measuring the excitability of the motor cortex, conclusions can be drawn as to the excitability of other cortical areas," says Schicktanz.

 

"The findings help us to understand the importance of neuronal excitability for cognitive processes in humans," adds Dr. Kyrill Schwegler, co-author of the study. The results might also have important clinical implications, as working memory deficits¹⁰ are a component¹¹ of many neuropsychiatric disorders¹³, such as schizophrenia or attention deficit⁹ hyperactivity disorder¹². In a next step, the scientists plan to study the relation between neuronal excitability and memory on a molecular¹⁴ level.

 

The study is part of a project lead by Prof. Dominique de Quervain and Prof. Andreas Papassotiropoulos. The project uses transcranial magnetic stimulation to study the cognitive functions in humans. The goal is to identify the neurobiological and molecular mechanisms¹⁵ of human memory.

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