As predators¹ go, cone² snails⁴ are slow-moving and lack the typical fighting parts. They've made up for it by producing a vast array of fast-acting toxins⁵ that target the nervous systems of prey⁶. A new study reveals that some cone snails add a weaponized form of insulin to the venom⁷ cocktail⁸ they use to disable fish. "It is very unlikely that it is serving a different purpose," said lead author Helena Safavi-Hemami, a research assistant professor at the University of Utah.

 

"This is a unique type of insulin. It is shorter than any insulin that has been described in any animal," said senior author Baldomero M. Olivera, a distinguished⁹ professor of biology at the University of Utah. "We found it in the venom in large amounts."

 

A synthetic¹⁰ form of the snail³ insulin, when injected into zebrafish, caused blood glucose¹¹ levels to plummet¹². The insulin also disrupted swimming behavior in fish exposed through water contact, as measured by the percentage of time spent swimming and frequency of movements. The researchers propose that adding insulin to the mix of venom toxins enabled predatory cone snails to disable entire schools of swimming fish with hypoglycemic shock. The study appears in Proceedings¹³ of the National Academy of Sciences.

 

Cone snails are abundant in most tropical marine¹⁴ waters, especially around coral reefs. Each species makes a distinct repertoire¹⁵ of venom compounds, mixtures that have evolved to target particular prey. Conus geographus, a cone snail that has killed dozens of people in accidental encounters, traps fish by releasing a blend of immobilizing venoms¹⁶ into the water, according to the prevailing¹⁷ hypothesis. The snail protrudes¹⁸ a stretchy mouth-like part and aims it like a gun barrel at fish, which become disoriented and stop moving even as the snail's mouth part slowly advances and engulfs¹⁹ the fish.

 

Seeking to understand how the cone snail springs its slow-motion trap, the Utah researchers searched the gene²⁰ sequences of all of the proteins expressed in the venom gland²¹ of Conus geographus. They found two sequences that looked surprisingly similar to that of the hormone²² insulin, used by humans and other vertebrate animals to regulate energy metabolism²³. The insulin genes²⁴ were more highly expressed in the venom gland than genes for some of the established venom toxins. One sequence proved very similar to that of fish insulin. Chemical analysis of venom confirmed that it contained abundant amounts of this insulin.

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