可以预测患乳腺癌危险的分子标记
文章来源:未知 文章作者:enread 发布时间:2016-04-08 06:53 字体: [ ]  进入论坛
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Harvard Stem Cell Institute (HSCI) researchers at Dana-Farber Cancer Institute (DFCI) and collaborators at Brigham and Women's Hospital (BWH) have identified a molecular1 marker in normal breast tissue that can predict a woman's risk for developing breast cancer, the leading cause of death in women with cancer worldwide. The work, led by HSCI principal faculty2 member Kornelia Polyak and Rulla Tamimi of BWH, was published in an early online release and in the April 1 issue of Cancer Research.
 
The study builds on Polyak's earlier research finding that women already identified as having a high risk of developing cancer -- namely those with a mutation3 called BRCA1 or BRCA2 -- or women who did not give birth before their 30s had a higher number of mammary gland4 progenitor5 cells.
 
In the latest study, Polyak, Tamimi, and their colleagues examined biopsies, some taken as many as four decades ago, from 302 participants in the Nurses' Health Study and the Nurses' Health Study II who had been diagnosed with benign6 breast disease. The researchers compared tissue from the 69 women who later developed cancer to the tissue from the 233 women who did not. They found that women were five times as likely to develop cancer if they had a higher percentage of Ki67, a molecular marker that identifies proliferating7 cells, in the cells that line the mammary ducts and milk-producing lobules. These cells, called the mammary epithelium, undergo drastic changes throughout a woman's life, and the majority of breast cancers originate in these tissues.
 
Doctors already test breast tumors for Ki67 levels, which can inform decisions about treatment, but this is the first time scientists have been able to link Ki67 to precancerous tissue and use it as a predictive tool.
 
"Instead of only telling women that they don't have cancer, we could test the biopsies and tell women if they were at high risk or low risk for developing breast cancer in the future," said Polyak, a breast cancer researcher at Dana-Farber and co-senior author of the paper.
 
"Currently, we are not able to do a very good job at distinguishing women at high and low risk of breast cancer," added co-senior author Tamimi, an associate professor at the Harvard T.H. Chan School of Public Health and Harvard Medical School. "By identifying women at high risk of breast cancer, we can better develop individualized screening and also target risk reducing strategies."


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1 molecular mE9xh     
adj.分子的;克分子的
参考例句:
  • The research will provide direct insight into molecular mechanisms.这项研究将使人能够直接地了解分子的机理。
  • For the pressure to become zero, molecular bombardment must cease.当压强趋近于零时,分子的碰撞就停止了。
2 faculty HhkzK     
n.才能;学院,系;(学院或系的)全体教学人员
参考例句:
  • He has a great faculty for learning foreign languages.他有学习外语的天赋。
  • He has the faculty of saying the right thing at the right time.他有在恰当的时候说恰当的话的才智。
3 mutation t1PyM     
n.变化,变异,转变
参考例句:
  • People who have this mutation need less sleep than others.有这种突变的人需要的睡眠比其他人少。
  • So far the discussion has centered entirely around mutation in the strict sense.到目前为止,严格来讲,讨论完全集中于围绕突变问题上。
4 gland qeGzu     
n.腺体,(机)密封压盖,填料盖
参考例句:
  • This is a snake's poison gland.这就是蛇的毒腺。
  • Her mother has an underactive adrenal gland.她的母亲肾上腺机能不全。
5 progenitor 2iiyD     
n.祖先,先驱
参考例句:
  • He was also a progenitor of seven presidents of Nicaragua.他也是尼加拉瓜7任总统的祖先。
  • Schoenberg was a progenitor of modern music.勋伯格是一位现代音乐的先驱。
6 benign 2t2zw     
adj.善良的,慈祥的;良性的,无危险的
参考例句:
  • The benign weather brought North America a bumper crop.温和的气候给北美带来大丰收。
  • Martha is a benign old lady.玛莎是个仁慈的老妇人。
7 proliferating 45e10aecc1d3b089f65dafcc7343579e     
激增( proliferate的现在分词 ); (迅速)繁殖; 增生; 扩散
参考例句:
  • Computerized data bases are proliferating fast. 计算机化的数据库正在激增。
  • Crown galls are cancerous growths composed of disorganized and proliferating plant cells. 冠瘿是无组织的正在不断增殖的植物细胞所组成的癌状物。
TAG标签: cancer breast molecular
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