Children exposed to secondhand cigarette smoke have an increased risk of developing lung cancer in adulthood¹成年, even if they never smoked. Results of this study are published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research, as part of a special tobacco focus in the December issue.

This year alone, more than 219,000 Americans will be diagnosed with lung cancer; more than 159,000 will die from it and some of those may be people who have never smoked. Studies to date have shown that exposure to secondhand smoke in adulthood has detrimental有害的 health effects, but data are limited on one's risk of developing lung cancer when exposed as a child.

What makes this study different from previous research is that it was conducted in two independent cohorts军团，同龄类 and included a molecular³ analysis of gene⁴ variants⁵ of innate⁶ immunity先天免疫 — the mannose甘露糖 binding⁸ lection-2 gene, or MBL2 gene. The MBL2 gene is known to affect susceptibility感受性，感情 to respiratory diseases呼吸系统疾病.

Using the ongoing⁹ National Cancer Institute-Maryland Lung Cancer study (624 cases; 348 controls), Curtis C. Harris, M.D., chief of the Laboratory of Human Carcinogenesis at NCI, and colleagues collected information on secondhand smoke history among men and women. They used DNA¹⁰ for genotyping the MBL2 gene. Then, to compare, Harris, Ping Yang, M.D., Ph.D., professor of epidemiology at the Mayo Clinic in Rochester, Minn., and colleagues used results from a Mayo Clinic study (461 never smokers¹¹; 172 cases; 289 controls).

Harris and colleagues found an association between childhood exposure to secondhand tobacco smoke and increased risk of lung cancer in adulthood. Furthermore, MBL2 activity was associated with an even more increased risk among those who were exposed to secondhand smoke in childhood.

Based on the results of this study, Harris said "children should not be exposed to secondhand tobacco smoke due to the long-term health implications含义，启示 they can face in adulthood." He added that these results warrant further investigation¹² in a larger study population.