A team of University of British Columbia researchers has identified fat-producing cells that possess "dual-personalities人身攻击，诽谤" and may further the development of treatments for muscle diseases such as muscular dystrophy营养障碍 and fibrosis纤维化. The team found a new type of fibro/adipogenic脂肪形成的 progenitors先觉者, or FAPs, that generate fatty fibrous tissues when transplanted into damaged muscles in mice. Progenitors¹ are similar to stem cells in their capacity to differentiate², but are limited in the number of times they can divide.

The findings are published in the current issue of Nature Cell Biology.

"These cells are typically dormant³静止的，休眠的 in muscle tissues," says lead author Fabio Rossi, Canada Research Chair in Regenerative Medicine. "Once activated⁴ by damage, they produce signals that coordinate⁵ tissue regeneration and then disappear. That's the Dr. Jekyll side of FAPs.

"In chronic⁶ muscle diseases such as muscular dystrophy肌肉萎缩症, however, FAPs persist and may be contributing to over-production of scar tissues, resulting in fibrosis. That's the Mr. Hyde side," says Rossi, associate professor in the Department of Medical Genetics and the Biomedical Research Centre.

Better understanding of the role of FAPs could help encourage their healthy function or repress their negative impact, the researchers say. In the long term, drugs targeting these cells may be useful in a range of diseases characterized by fibrosis ranging from cardiovascular to lung and kidney disease, to organ transplantation. In addition, the cells' ability to generate new fat tissue could be exploited to target metabolic⁷ disease代谢性疾病.