UC Irvine researchers have played a leading role in the genome sequencing of Hydra¹, a freshwater polyp（珊瑚虫，水螅虫） that has been a staple²（主题） of biological research for 300 years. In the March 14 online version of Nature, UCI biologists Robert Steele and Hans Bode³, along with nine other UCI scientists and an international team of researchers, describe the genome sequence of an organism that continues to advance research on regeneration, stem cells and patterning.

The team discovered Hydra to have about the same number of genes⁴ as humans, sharing many of the same ones. Surprisingly, they also found genes linked with Huntington's disease and with the beta-amyloid（含淀粉的） plaque（饰板，血小板） formation seen in Alzheimer's disease – two areas in which UCI has traditionally strong research programs – suggesting the possible use of Hydra as a research model for these two diseases.

"Having the Hydra genome sequenced also enhances our ability to use it to learn more about the basic biology of stem cells, which are showing great promise for new treatments for a host of（许多，大量） injuries and diseases," said Steele, associate professor and interim⁵（临时的，中间的） chair in biological chemistry.

Started in 2004, the Hydra project is the first genome sequencing effort in which UCI scientists have played a major role. The sequencing was carried out at the J. Craig Venter Institute and was funded by the National Human Genome Research Institute.