Nanoparticles could help smuggle¹ drugs into the gut²（内脏，肠子） , according to a study published this month in the International Journal of Nanotechnology. There are several drugs that would have more beneficial therapeutic³ effects if they could be targeted at absorption by the lower intestine⁴（肠） . However, in order to target the colon⁵ for treating colon cancer for instance, medication delivered by mouth must surmount⁶（克服，战胜） several barriers including stomach acidity⁷, binding⁸ to mucus（黏液） layers, rapid clearance⁹ from the gut, and premature¹⁰ uptake by cells higher up the gastrointestinal tract¹¹（胃肠道） . Being able to deliver a drug by mouth has several benefits over injection or suppository: ease of dosing, for instance, and better patient compliance¹².

Various methods have been tried, including coating drug molecules¹⁴ with a polymer shell. However, Kevin P. O'Donnell and Robert O. Williams III of the Division of Pharmaceutics¹⁵, at The University of Texas at Austin, have reviewed the various techniques on offer and suggest that encapsulating a drug molecule¹³ within nanoparticles offers the best option for controlling drug delivery and targeting the colon.

The Texas team has reviewed the state of the art in nanotechnology for delivery of therapeutic agents to the colon. They explain that advances in particle engineering techniques have recently made it possible to made drug products on the nanoscale. Techniques such as spray drying, antisolvent methods, dialysis methods, emulsion（乳剂） methods and cryogenic（冷冻的） methods are all now available for drug formulation. Converting a drug powder into nanoparticles can often render a compound that is poorly soluble¹⁶ in water soluble or increase bioavailability simply through an increase in the surface area to volume ratio. Smaller particles mean a bigger surface area to interact with absorbing surfaces in the gastrointestinal tract. Indeed, fatty but solid nanoparticles of the compound quercetin (a health supplement) are absorbed almost 6 times more effectively by the gut in nanoparticle form than the common drug suspension formulation.

The researchers explain that nanoparticle drug delivery could be particularly beneficial for patients suffering from inflammatory bowel¹⁷ diseases including Crohn's Disease, ulcerative colitis（溃疡性结肠炎） and irritable¹⁸ bowel syndrome¹⁹, all which often require long-term treatment. However, they also add that because there are no digestive enzymes²⁰ in the colon and its neutral pH it is a prime target for the delivery of therapeutic proteins, peptides（多肽类，缩氨酸） , viral vectors, and nucleotides（核苷酸） for a wide range of disease not simply those associated with the colon.