维生素D缺乏易导致肺功能受损
文章来源:未知 文章作者:enread 发布时间:2011-01-31 01:46 字体: [ ]  进入论坛
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Previously1 linked to the severity of asthma2(哮喘) and chronic3 obstructive pulmonary disease (COPD慢性阻塞性肺病) in humans, vitamin D deficiency has now been shown to alter lung structure and function in young mice. The new study, conducted by researchers in Australia, offers the first concrete evidence linking vitamin D deficiency with deficits4 in lung function and altered lung structure. The findings were published online ahead of the print edition of the American Thoracic Society's American Journal of Respiratory(呼吸的) and Critical Care Medicine.

"The results of this study clearly demonstrate that vitamin D deficiency alters lung growth, resulting in lower lung volume and decrements(减缩) in lung function," said Graeme Zosky, PhD, a research fellow at the Telethon Institute for Child Health Research in Subiaco, Australia. "This is the first direct mechanistic evidence showing that vitamin D deficiency alters lung development, which may explain the association between obstructive lung disease and levels of vitamin D."

To conduct their study, the researchers used a mouse model of vitamin D deficiency and evaluated lung responses of two-week-old mice, comparing them to control mice without vitamin D deficiency to determine what, if any, effects the deficiency may have caused in the growth, structure or function of the lungs.

Lung volume and lung function were evaluated using a plethysmograph(体积扫描器) , an instrument used to measure the amount of air in the lung, and via forced oscillation(受迫振动) , a technique used to measure the resistance to air flow in the lungs. Microscopic5 lung tissue samples were also evaluated to assess changes in lung structure.

"The aim of this study was to determine if vitamin D deficiency results in altered lung function and/or structure as a potential explanation for the association between vitamin D and chronic respiratory disease," said Dr. Zosky, who is also an adjunct(附属的) senior lecturer at the University of Western Australia's Centre for Child Health Research. "Specifically, we aimed to determine if vitamin D deficiency has an influence on lung growth as indicated by a decrease in lung volume. We also wanted to determine if the deficiency alters the mechanical properties of the lung tissue due to changes in the structure of the lung."

The researchers found that airway6 resistance was significantly higher while lung volume was significantly lower in vitamin D-deficient7 mice compared to control mice. Examinations of specific tissue responses revealed model mice had reduced lung function. Lungs were also smaller in model mice, which Dr. Zosky said could have been caused by the deficiencies of the mother or of the offspring.

"Due to the nature of this study, we were not able to determine whether the differences in lung size and function we observed in the deficient offspring were the result of their own deficient status or as a consequence of developmental deficits that occurred in utero(子宫) due to the mother's deficiency," he said.

Dr. Zosky noted8 that although recent studies suggest that vitamin D deficiency is associated with reduced lung function, causal data confirming a relationship between vitamin D and lung function have been lacking.

"For the first time, we have demonstrated a direct role for vitamin D in causing decreased lung function in the absence of known confounders such as physical inactivity, confirming the assertion by epidemiological(流行病学的) studies that there is a relationship between vitamin D deficiency and lung function," Dr. Zosky said. "The differences we observed in lung volume and lung mechanics, which were substantial and physiologically9 relevant, raise serious concerns regarding the increased prevalence of vitamin D deficiency in communities around the world. The results also raise concerns about the potential this deficiency may have on lung health, and in particular, the potential impact deficiency may have on the susceptibility to obstructive lung disease."

Dr. Zosky said the study results have important implications for prevention of lung diseases in populations where vitamin D deficiencies are common. Future studies need to be conducted to determine whether vitamin D deficiency-induced alterations10 in lung growth increase the severity of obstructive lung disease and to identify susceptible11 populations whose use of dietary vitamin D supplementation could be used to improve lung health outcomes, he added.



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1 previously bkzzzC     
adv.以前,先前(地)
参考例句:
  • The bicycle tyre blew out at a previously damaged point.自行车胎在以前损坏过的地方又爆开了。
  • Let me digress for a moment and explain what had happened previously.让我岔开一会儿,解释原先发生了什么。
2 asthma WvezQ     
n.气喘病,哮喘病
参考例句:
  • I think he's having an asthma attack.我想他现在是哮喘病发作了。
  • Its presence in allergic asthma is well known.它在过敏性气喘中的存在是大家很熟悉的。
3 chronic BO9zl     
adj.(疾病)长期未愈的,慢性的;极坏的
参考例句:
  • Famine differs from chronic malnutrition.饥荒不同于慢性营养不良。
  • Chronic poisoning may lead to death from inanition.慢性中毒也可能由虚弱导致死亡。
4 deficits 08e04c986818dbc337627eabec5b794e     
n.不足额( deficit的名词复数 );赤字;亏空;亏损
参考例句:
  • The Ministry of Finance consistently overestimated its budget deficits. 财政部一贯高估预算赤字。 来自《简明英汉词典》
  • Many of the world's farmers are also incurring economic deficits. 世界上许多农民还在遭受经济上的亏损。 来自辞典例句
5 microscopic nDrxq     
adj.微小的,细微的,极小的,显微的
参考例句:
  • It's impossible to read his microscopic handwriting.不可能看清他那极小的书写字迹。
  • A plant's lungs are the microscopic pores in its leaves.植物的肺就是其叶片上微细的气孔。
6 airway xzez8W     
n.空中航线,通风口
参考例句:
  • Lay them on their side and ensure the airway is unobstructed.让他们侧躺着,并确保呼吸道畅通。
  • There is a purple airway in London Airport.伦敦机场里有一条皇家专用飞机跑道。
7 deficient Cmszv     
adj.不足的,不充份的,有缺陷的
参考例句:
  • The crops are suffering from deficient rain.庄稼因雨量不足而遭受损害。
  • I always have been deficient in selfconfidence and decision.我向来缺乏自信和果断。
8 noted 5n4zXc     
adj.著名的,知名的
参考例句:
  • The local hotel is noted for its good table.当地的那家酒店以餐食精美而著称。
  • Jim is noted for arriving late for work.吉姆上班迟到出了名。
9 physiologically QNfx3     
ad.生理上,在生理学上
参考例句:
  • Therefore, the liver and gallbladder cannot be completely separated physiologically and pathologically. 因此,肝胆在生理和病理上不能完全分离。
  • Therefore, the liver and gallbladder are closely related physiologically and pathologically. 因此,肝胆在生理和病理上紧密联系。
10 alterations c8302d4e0b3c212bc802c7294057f1cb     
n.改动( alteration的名词复数 );更改;变化;改变
参考例句:
  • Any alterations should be written in neatly to the left side. 改动部分应书写清晰,插在正文的左侧。 来自《简明英汉词典》
  • Gene mutations are alterations in the DNA code. 基因突变是指DNA 密码的改变。 来自《简明英汉词典》
11 susceptible 4rrw7     
adj.过敏的,敏感的;易动感情的,易受感动的
参考例句:
  • Children are more susceptible than adults.孩子比成人易受感动。
  • We are all susceptible to advertising.我们都易受广告的影响。
TAG标签: vitamin lung deficiency
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