A lack of vitamin D, even in generally healthy people, is linked with stiffer arteries¹ and an inability of blood vessels² to relax, research from the Emory/Georgia Tech Predictive Health Institute has found. The results add to evidence that lack of vitamin D can lead to impaired³ vascular⁴（血管的） health, contributing to high blood pressure and the risk of cardiovascular disease. Study participants who increased their vitamin D levels were able to improve vascular health and lower their blood pressure.

The data is being presented on Sunday by Ibhar Al Mheid, MD, a cardiovascular researcher at Emory University School of Medicine, at the annual American College of Cardiology meeting in New Orleans. Al Mheid is one of five finalists for the ACC's Young Investigators⁵ Award competition in physiology⁶, pharmacology and pathology. He is working with Arshed Quyyumi, MD, professor of medicine and director of the Emory Cardiovascular Research Institute.

The 554 participants in the study were Emory or Georgia Tech employees –average age 47 and generally healthy -- who are taking part in the Center for Health Discovery and Well Being, part of the Emory/Georgia Tech Predictive Health Institute.

The average level of 25-hydroxyvitamin D (a stable form of the vitamin reflecting diet as well as production in the skin) in participants' blood was 31.8 nanograms per milliliter. In this group, 14 percent had 25-hydroxyvitamin D levels considered deficient⁷, or less than 20 nanograms per milliliter, and 33 percent had levels considered insufficient⁸, less than 30 nanograms per milliliter.

The researchers monitored the ability of participants' blood vessels to relax by inflating⁹ and then removing a blood pressure cuff¹⁰ on their arms. To allow blood to flow back into the arm, blood vessels must relax and enlarge – a change that can be measured by ultrasound. The researchers also made other measurements of smaller blood vessels and examined the resistance to blood flow imposed by the arteries.

Even after controlling for factors such as age, weight and cholesterol¹¹, people with lower vitamin D levels still had stiffer arteries and impaired vascular function, Al Mheid says.

"We found that people with vitamin D deficiency had vascular dysfunction comparable to those with diabetes¹² or hypertension," he says.

Throughout the body, a layer of endothelial cells（内皮细胞） lines the blood vessels, controlling whether the blood vessels constrict¹³ or relax and helping¹⁴ to prevent clots¹⁵（血块） that lead to strokes and heart attacks.

"There is already a lot known about how vitamin D could be acting¹⁶ here," Al Mheid says. "It could be strengthening endothelial cells and the muscles surrounding the blood vessels. It could also be reducing the level of angiotensin, a hormone¹⁷ that drives increased blood pressure, or regulating inflammation."