Although cytomegalovirus（巨细胞病毒） infection is a known cause of birth defects, including permanent hearing loss, most CMV infections in infants are not identified early, when interventions¹ can lessen² the effects of hearing loss. Now, Suresh Boppana, M.D., and Karen Fowler, Dr.P.H., from the University of Alabama at Birmingham and colleagues from other academic medical centers report that a polymerase（聚合酶） chain-reaction (PCR)-based saliva³ test can identify CMV in newborns with greater than 97 percent accuracy. The traditional testing method, a “rapid culture” saliva test, is also accurate, but Boppana says it is not feasible to screen a large number of babies because of its expense, the time it takes for results and the requirement for a tissue culture facility.

The findings from their multi-center study will be published in the June 2, 2011, issue of the New England Journal of Medicine.

"Our objective was to find what method could test for CMV in a larger sample, rapidly, reliably and relatively⁴ inexpensively, we found that testing saliva works well," says Boppana, a professor of Pediatric Infectious Diseases and the paper's corresponding author.

According to the Centers for Disease Control and Prevention, one in 150 babies will be born with CMV. "When you look at babies in the nursery, you don't even know which ones are infected; they're like any other baby in there," Boppana says.

There is currently no cure for CMV infection or even a clear connection between CMV and hearing loss. But Boppana says babies should still be tested within the first two to three weeks of birth. The sooner doctors know a baby is infected with CMV, the better they can monitor and intervene if a child develops hearing loss. Those interventions include speech therapy, hearing aids, cochlear implants⁵（人工耳蜗） and physical therapy.

CMV is the most common infection passed from a mother to her unborn child, and there is no vaccine⁶ for it. "If a pregnant woman acquires CMV for the first time during pregnancy⁷, then the chances of her passing it on to the baby are 30 to 60 percent," Boppana says.

Fowler says there are a variety of ways that a mother can contract CMV.

"Often mothers get the virus through exposure to young children — children in the household or their friends' children or children who have been in day care. But CMV also can be transmitted between adults sexually," says Fowler, also a professor of Pediatric（小儿科的） Infectious Diseases.

Some 35,000 babies were tested for CMV with the saliva assay⁸ during the study. Infants who tested positive will be enrolled⁹ in a follow-up program to monitor their hearing every six months until they are 4 years old.