Cdc42蛋白质影响细胞的生长繁殖
文章来源:未知 文章作者:enread 发布时间:2012-05-21 06:05 字体: [ ]  进入论坛
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A collaboration1 between Lehigh University physicists2 and University of Miami biologists addresses an important fundamental question in basic cell biology: How do living cells figure out when and where to grow? The study, "Oscillatory Dynamics3 of Cdc42 GTPase In The Control of Polarized Growth," appears May 18 in the journal Science Express.

Assistant Professor Dimitrios Vavylonis and graduate student Tyler Drake joined a University of Miami research team led by Associate Professor Fulvia Verde to learn that protein Cdc42 begins the ballet of proteins that change cell polarity, by oscillating(振荡的) throughout the cellular4 membrane5 of new cells. By changing polarity, Cdc42 regulates shape, structure and function in yeast6 cells. This oscillatory mechanism7 may be a general strategy among all self-organizing biological systems, not just simple yeast.

Researchers used fluorescent8(荧光的) markers to tag each of the many proteins involved, observing the protein oscillate, switching sides about every five minutes. The fluctuations9 provide an adaptable10 mechanism for cells to control their size and structure in the fast-changing environment within.

The findings demonstrate just part of the complex process of cell growth and differentiation11, but mark how advanced the science of biophysics has become. Only recently has the clear imaging and monitoring of protein activity become possible at the minute sizes and shortened time scales of individual cell maturation.

Vavylonis's research has for years explored the way the cellular cytoskeleton organizes and functions. In collaboration with biologists and computer scientists, his team uses physics to study, analyze12, and model the physical properties of these adaptive biological materials.

The study was funded by the National Science Foundation, the National Institutes of Health, and by individual university groups including a Lehigh Class of 1968 Junior Faculty13 Fellowship and a Sigma Xi grant to Drake.



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1 collaboration bW7yD     
n.合作,协作;勾结
参考例句:
  • The two companies are working in close collaboration each other.这两家公司密切合作。
  • He was shot for collaboration with the enemy.他因通敌而被枪毙了。
2 physicists 18316b43c980524885c1a898ed1528b1     
物理学家( physicist的名词复数 )
参考例句:
  • For many particle physicists, however, it was a year of frustration. 对于许多粒子物理学家来说,这是受挫折的一年。 来自英汉非文学 - 科技
  • Physicists seek rules or patterns to provide a framework. 物理学家寻求用法则或图式来构成一个框架。
3 dynamics NuSzQq     
n.力学,动力学,动力,原动力;动态
参考例句:
  • In order to succeed,you must master complicated knowledge of dynamics.要取得胜利,你必须掌握很复杂的动力学知识。
  • Dynamics is a discipline that cannot be mastered without extensive practice.动力学是一门不做大量习题就不能掌握的学科。
4 cellular aU1yo     
adj.移动的;细胞的,由细胞组成的
参考例句:
  • She has a cellular telephone in her car.她的汽车里有一部无线通讯电话机。
  • Many people use cellular materials as sensitive elements in hygrometers.很多人用蜂窝状的材料作为测量温度的传感元件。
5 membrane H7ez8     
n.薄膜,膜皮,羊皮纸
参考例句:
  • A vibrating membrane in the ear helps to convey sounds to the brain.耳膜的振动帮助声音传送到大脑。
  • A plastic membrane serves as selective diffusion barrier.一层塑料薄膜起着选择性渗透屏障的作用。
6 yeast 7VIzu     
n.酵母;酵母片;泡沫;v.发酵;起泡沫
参考例句:
  • Yeast can be used in making beer and bread.酵母可用于酿啤酒和发面包。
  • The yeast began to work.酵母开始发酵。
7 mechanism zCWxr     
n.机械装置;机构,结构
参考例句:
  • The bones and muscles are parts of the mechanism of the body.骨骼和肌肉是人体的组成部件。
  • The mechanism of the machine is very complicated.这台机器的结构是非常复杂的。
8 fluorescent Zz2y3     
adj.荧光的,发出荧光的
参考例句:
  • They observed the deflections of the particles by allowing them to fall on a fluorescent screen.他们让粒子落在荧光屏上以观察他们的偏移。
  • This fluorescent lighting certainly gives the food a peculiar color.这萤光灯当然增添了食物特别的色彩。
9 fluctuations 5ffd9bfff797526ec241b97cfb872d61     
波动,涨落,起伏( fluctuation的名词复数 )
参考例句:
  • He showed the price fluctuations in a statistical table. 他用统计表显示价格的波动。
  • There were so many unpredictable fluctuations on the Stock Exchange. 股票市场瞬息万变。
10 adaptable vJDyI     
adj.能适应的,适应性强的,可改编的
参考例句:
  • He is an adaptable man and will soon learn the new work.他是个适应性很强的人,很快就将学会这种工作。
  • The soil is adaptable to the growth of peanuts.这土壤适宜于花生的生长。
11 differentiation wuozfs     
n.区别,区分
参考例句:
  • There can be no differentiation without contrast. 有比较才有差别。
  • The operation that is the inverse of differentiation is called integration. 与微分相反的运算叫做积分。
12 analyze RwUzm     
vt.分析,解析 (=analyse)
参考例句:
  • We should analyze the cause and effect of this event.我们应该分析这场事变的因果。
  • The teacher tried to analyze the cause of our failure.老师设法分析我们失败的原因。
13 faculty HhkzK     
n.才能;学院,系;(学院或系的)全体教学人员
参考例句:
  • He has a great faculty for learning foreign languages.他有学习外语的天赋。
  • He has the faculty of saying the right thing at the right time.他有在恰当的时候说恰当的话的才智。
TAG标签: cells growth proteins
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