酗酒影响骨愈合
文章来源:未知 文章作者:enread 发布时间:2013-10-20 07:42 字体: [ ]  进入论坛
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Physicians have long observed that binge drinking(酗酒,豪饮) can significantly impair1 the healing process following a bone fracture. Now a study by Loyola University Medical Center researchers is providing insights into how alcohol slows healing on the cellular2 and molecular3 levels. The findings could lead to treatments to improve bone healing in alcohol abusers, and possibly non-drinkers as well.
 
Roman Natoli, MD, PhD, will present findings Oct. 6 during the American Society for Bone and Mineral Research 2013 Annual Meeting in Baltimore. Senior author is John Callaci, PhD. The study was funded by the Orthopaedic Research and Education Foundation.
 
"Many bone fractures are alcohol-related, due to car accidents, falls, shootings, etc.," Natoli said. "In addition to contributing to bone fractures, alcohol also impairs4 the healing process. So add this to the list of reasons why you should not abuse alcohol."
 
Researchers studied the effects that alcohol consumption had on bone healing in mice. One group of mice was exposed to alcohol levels roughly equivalent to three times the legal limit for driving. A control group was exposed to equal amounts of saline(盐湖) (salt water).
 
The study found three ways in which alcohol impaired5 bone healing after a fracture:
 
 There were differences between the control group and the alcohol-exposed group in the callus(愈合组织,老茧), the hard bony tissue that forms around the ends of fractured bones. In the alcohol-exposed group, the callus was less mineralized, meaning not as much bone was forming. Moreover, the bone that did form was not as strong.
 
 Mice exposed to alcohol showed signs of oxidative stress, a process that impairs normal cellular functions. The alcohol-exposed mice had significantly higher levels of malondialdehyde(丙二醛), a molecule6 that serves as a marker for oxidative stress. Additionally, levels of an enzyme7 that decreases oxidative stress, super oxide8 dismutase, were higher in the alcohol-exposed mice (but not quite high enough to be considered statistically9 significant).
 
 During the healing process, the body sends immature10 stem cells to a fracture site. After arriving at the site, the stem cells mature into bone cells. Two proteins, known as SDF-1 and OPN, are involved in recruiting stem cells to the injury site. In the alcohol-exposed group, OPN levels were significantly lower.
 
As a follow up to this study, Natoli is planning an animal-model study on two potential treatments to counter the negative effects of alcohol on bone healing. One treatment would be to inject mice with stem cells to improve healing. The other treatment would be the administration of NAc, an antioxidant that combats oxidative stress.
 
If such treatments were shown to be effective in alcohol abusers, it's possible the treatments also might speed healing in non-drinkers as well, Natoli said.
 
Natoli is a resident physician in the Department of Orthopaedic Surgery and Rehabilitation11 at Loyola University Chicago Stritch School of Medicine. Callaci is an assistant professor in the Department of Orthopaedic Surgery and Rehabilitation. The third author is Rachel Mauer, BS, a research technician.


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1 impair Ia4x2     
v.损害,损伤;削弱,减少
参考例句:
  • Loud noise can impair your hearing.巨大的噪音有损听觉。
  • It can not impair the intellectual vigor of the young.这不能磨灭青年人思想活力。
2 cellular aU1yo     
adj.移动的;细胞的,由细胞组成的
参考例句:
  • She has a cellular telephone in her car.她的汽车里有一部无线通讯电话机。
  • Many people use cellular materials as sensitive elements in hygrometers.很多人用蜂窝状的材料作为测量温度的传感元件。
3 molecular mE9xh     
adj.分子的;克分子的
参考例句:
  • The research will provide direct insight into molecular mechanisms.这项研究将使人能够直接地了解分子的机理。
  • For the pressure to become zero, molecular bombardment must cease.当压强趋近于零时,分子的碰撞就停止了。
4 impairs 866bc0da43dd90e04b6073750ff1e87c     
v.损害,削弱( impair的第三人称单数 )
参考例句:
  • Smoking impairs our health. 吸烟会损害我们的健康。 来自《简明英汉词典》
  • Almost anything that impairs liver function can cause hepatitis. 任何有损于肝功能的因素,几乎都会引起肝炎。 来自辞典例句
5 impaired sqtzdr     
adj.受损的;出毛病的;有(身体或智力)缺陷的v.损害,削弱( impair的过去式和过去分词 )
参考例句:
  • Much reading has impaired his vision. 大量读书损害了他的视力。 来自《现代汉英综合大词典》
  • His hearing is somewhat impaired. 他的听觉已受到一定程度的损害。 来自《现代汉英综合大词典》
6 molecule Y6Tzn     
n.分子,克分子
参考例句:
  • A molecule of water is made up of two atoms of hygrogen and one atom of oxygen.一个水分子是由P妈?f婘??妈?成的。
  • This gives us the structural formula of the molecule.这种方式给出了分子的结构式。
7 enzyme cPozF     
n.酵素,酶
参考例句:
  • Above a certain temperature,the enzyme molecule will become unfolded.超过一定温度,酶分子将会展开。
  • An enzyme that dissolves the fibrin of blood clots.能溶解血凝块中的纤维的酶。
8 oxide K4dz8     
n.氧化物
参考例句:
  • Oxide is usually seen in our daily life.在我们的日常生活中氧化物很常见。
  • How can you get rid of this oxide coating?你们该怎样除去这些氧化皮?
9 statistically Yuxwa     
ad.根据统计数据来看,从统计学的观点来看
参考例句:
  • The sample of building permits is larger and therefore, statistically satisfying. 建筑许可数的样本比较大,所以统计数据更令人满意。
  • The results of each test would have to be statistically independent. 每次试验的结果在统计上必须是独立的。
10 immature Saaxj     
adj.未成熟的,发育未全的,未充分发展的
参考例句:
  • Tony seemed very shallow and immature.托尼看起来好像很肤浅,不夠成熟。
  • The birds were in immature plumage.这些鸟儿羽翅未全。
11 rehabilitation 8Vcxv     
n.康复,悔过自新,修复,复兴,复职,复位
参考例句:
  • He's booked himself into a rehabilitation clinic.他自己联系了一家康复诊所。
  • No one can really make me rehabilitation of injuries.已经没有人可以真正令我的伤康复了。
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