Laser physicists¹ have found a way to make atomic-force microscope probes 20 times more sensitive and capable of detecting forces as small as the weight of an individual virus. The technique, developed by researchers at The Australian National University (ANU), hinges on（取决于） using laser beams to cool a nanowire probe to minus 265 degrees Celsius².

 

"The level of sensitivity achieved after cooling is accurate enough for us to sense the weight of a large virus that is 100 billion times lighter³ than a mosquito," said Dr Ben Buchler from the ANU Research School of Physics and Engineering.

 

The development could be used to improve the resolution of atomic-force microscopes, which are the state-of-the-art tool for measuring nanoscopic structures and the tiny forces between molecules⁴.

 

Atomic force microscopes achieve extraordinarily⁵ sensitivity measurements of microscopic⁶ features by scanning a wire probe over a surface.

 

However, the probes, around 500 times finer than a human hair, are prone⁷ to vibration⁸.

 

"At room temperature the probe vibrates, just because it is warm, and this can make your measurements noisy," said Professor Ping Koy Lam, a co-author of the research that is published in Nature Communications.

 

"We can stop this motion by shining lasers at the probe," he said.

 

The force sensor⁹ used by the ANU team was a 200 nm-wide silver gallium（镓） nanowire coated with gold.

 

"The laser makes the probe warp¹⁰ and move due to heat. But we have learned to control this warping¹¹ effect and were able to use the effect to counter the thermal¹² vibration of the probe," said Giovanni Guccione, a PhD student on the team.

 

However, the probe cannot be used while the laser is on as the laser effect overwhelms the sensitive probe. So the laser has to be turned off and any measurements quickly made before the probe heats up within a few milliseconds. By making measurements over a number of cycles of heating and cooling, an accurate value can be found.

 

"We now understand this cooling effect really well," says PhD student Harry¹³ Slatyer. "With clever data processing we might be able to improve the sensitivity, and even eliminate the need for a cooling laser."

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