It's no surprise that some frogs
secrete1 poison from
glands2 in their skin. But researchers reporting in the Cell Press journal Current Biology on August 6 have discovered the first two species of frog, both living in Brazil, that are actually venomous. Not only do the frogs produce
potent3 toxins4, but they also have a
mechanism5 to deliver those harmful
secretions7 into another animal using bony
spines8 on their heads. "Discovering a truly venomous frog is nothing any of us expected, and finding frogs with skin secretions more venomous than those of the deadly pit
vipers9 of the genus Bothrops was astounding," says Edmund Brodie, Jr. of Utah State University.
The frogs in question, Corythomantis greeningi and Aparasphenodon brunoi, have both been known for many decades, if not centuries. But scientists have known little of their biology. The frogs have no known
predators10, which makes perfect sense in light of these latest findings.
Brodie and Carlos Jared of Instituto Butantan in São Paulo have both studied predator-prey systems of
amphibians11 for their entire careers. Unfortunately for Jared, he first realized that C. greeningi might be venomous firsthand while collecting frogs for research. His hand was injured by one of the frog's spines, which led to intense, radiating pain for a period of about 5 hours.
Needless to say, that event got the researchers' attention. "This action should be even more effective on the mouth
lining12 of an attacking predator," Jared says.
There was a bit of luck: the species that got Jared was the less
toxic13 of the two.
The researchers' calculations suggest that a single gram of the toxic
secretion6 from the other frog species, A. brunoi, would be enough to kill more than 300,000 mice or about 80 humans.