Scientists have revealed never-before-seen details of how our brain sends rapid-fire messages between its cells. They mapped the 3-D atomic structure of a two-part protein complex that controls the release of signaling chemicals, called neurotransmitters, from brain cells. Understanding how cells release those signals in less than one-thousandth of a second could help launch a new wave of research on drugs for treating brain disorders¹. The experiments, at the Linac Coherent Light Source (LCLS) X-ray laser at the Department of Energy's SLAC National Accelerator Laboratory, build upon decades of previous research at Stanford University, Stanford School of Medicine and SLAC. Researchers reported their latest findings today in the journal Nature.

 

"This is a very important, exciting advance that may open up possibilities for targeting new drugs to control neurotransmitter release. Many mental disorders, including depression, schizophrenia and anxiety, affect neurotransmitter systems," said Axel Brunger, the study's principal investigator². He is a professor at Stanford School of Medicine and SLAC and a Howard Hughes Medical Institute investigator.

 

"Both parts of this protein complex are essential," Brunger said, "but until now it was unclear how its two pieces fit and work together."

 

The two protein parts are known as neuronal SNAREs⁴ and synaptotagmin-1.

 

Earlier X-ray studies, including experiments at SLAC's Stanford Synchrotron Radiation Lightsource (SSRL) nearly two decades ago, shed light on the structure of the SNARE³ complex, a helical protein bundle found in yeasts⁵ and mammals. SNAREs play a key role in the brain's chemical signaling by joining, or "fusing," little packets of neurotransmitters to the outer edges of neurons, where they are released and then dock with chemical receptors in another neuron to trigger a response.

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