New software could speed up breast cancer diagnosis¹ with 90% accuracy without the need for a specialist, according to research published in the open access journal Breast Cancer Research. This could improve breast cancer management, particularly in developing countries where pathologists are not routinely available. "To evaluate fresh breast tissue at the point of care could change the current practice of pathology," says Rebecca Richards-Kortum, Rice University, Houston, Texas. "We have developed a faster means to classify benign² and malignant³ human breast tissues using fresh samples and thereby⁴ removing the need for time consuming tissue preparation."

 

Today, breast cancer diagnosis is an intricate process. Firstly, tissue has to be obtained, then rigorously prepared and assessed, whether this is in the context of core needle biopsy diagnosis or surgical⁵ excision⁶. Pathologists must currently undergo a complex method to prepare tissue samples for assessment⁷ and this is followed by a lengthy⁸ diagnosis process. 

 

The researchers used high speed optical microscopy of intact breast tissue specimens⁹ to analyze¹⁰ breast tissue. This automated¹¹ method for diagnosing breast cancer from tissue samples is performed without the need for complex tissue sample preparation or assessment by a specialist pathologist. 

 

"We performed our analysis without tissue fixation, cutting and staining and achieved comparable classification with current methods. This cuts out the tissue preparation process and allows for rapid diagnosis. It is also reliant on measurable criteria¹², which could reduce subjectivity¹³ in the evaluation¹⁴ of breast histology," says Rebecca Richards-Kortum.

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