At the flip¹ of a switch, University of California, Berkeley, neuroscientists can send a sleeping mouse into dreamland. The researchers inserted an optogenetic switch into a group of nerve cells located in the ancient part of the brain called the medulla, allowing them to activate² or inactivate³ the neurons with laser light. 

 

When the neurons were activated⁴, sleeping mice entered REM sleep within seconds. REM sleep, characterized by rapid eye movements, is the dream state in mammals accompanied by activation⁵ of the cortex and total paralysis⁶ of the skeletal muscles, presumably so that we don't act out the dreams flashing through our mind.

 

Inactivating⁷ the neurons reduced or even eliminated a mouse's ability to enter REM sleep.

 

"People used to think that this region of the medulla was only involved in the paralysis of skeletal muscles during REM sleep," said lead author Yang Dan, a UC Berkeley professor of molecular⁹ and cell biology and a Howard Hughes Medical Institute Investigator¹⁰. "What we showed is that these neurons triggered all aspects of REM sleep, including muscle paralysis and the typical cortical activation that makes the brain look more awake than in non-REM sleep."

 

While other types of neurons in the brainstem and hypothalamus have been shown to influence REM sleep, Dan said, "Because of the strong induction¹¹ of REM sleep - in 94 percent of the recorded trials our mice entered REM sleep within seconds of activating⁸ the neurons - we think this might be a critical node of a relatively¹² small network that makes the decision whether you go into dream sleep or not."

 

The UC Berkeley team reported their results in the Oct. 15 print issue of the British journal Nature, and the paper was posted online Oct. 7.

 

The discovery will not only help researchers better understand the complex control of sleep and dreaming in the brain, the researchers said, but will allow scientists to stop and start dreaming at will in mice to learn why we dream.

 

"Many psychiatric disorders¹³, especially mood disorders, are correlated with changes in REM sleep, and some widely used drugs affect REM sleep, so it seems to be a sensitive indicator¹⁴ of mental and emotional health," said first author Franz Weber, a UC Berkeley postdoctoral fellow. "We are hoping that studying the sleep circuit might lead us to new insights into these disorders as well as neurological diseases that affect sleep, like Parkinson's and Alzheimer's diseases."

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