Biologists at Tufts University have succeeded in inducing one species of flatworm to grow heads and brains characteristic of another species of flatworm without altering genomic sequence. The work reveals physiological¹ circuits as a new kind of epigenetics - information existing outside of genomic sequence - that determines large-scale anatomy². The finding that head shape is not hard-wired by the genome but can be overridden³ by manipulating electrical synapses⁴ in the body suggests that differences in species could be determined⁵ in part by the activity of bioelectrical networks. The discovery could help improve understanding of birth defects and regeneration by revealing a new pathway for controlling complex pattern formation. It has long been known that neural⁶ networks exploit bioelectric synapses to store and re-write information in the brain. 

 

The findings are detailed⁷ in the cover story of the November 2015 edition of the International Journal of Molecular⁸ Sciences, appearing online Nov. 24.

 

"It is commonly thought that the sequence and structure of chromatin - material that makes up chromosomes⁹ - determine the shape of an organism, but these results show that the function of physiological networks can override¹⁰ the species-specific default anatomy," says the paper's senior and corresponding author Michael Levin, Ph.D., who holds the Vannevar Bush Chair in biology and directs the Center for Regenerative and Developmental Biology in the School of Arts and Sciences at Tufts. "By modulating¹¹ the connectivity of cells via electrical synapses, we were able to derive¹² head morphology and brain patterning belonging to a completely different species from an animal with a normal genome."

 

Knowing how shape is determined and how to influence it is important because biologists could use that knowledge, for example, to fix birth defects or cause new biological structures to grow after an injury, adds Levin. "These findings raise significant questions about how genes¹³ and bioelectric networks interact to build complex body structures," he says.

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