Corals are an invaluable¹ part of the marine² ecosystem³, fostering biodiversity and protecting coastlines. But they're also increasingly endangered. Pathogenic bacteria, along with pollution and harmful fishing practices, are one of the biggest threats to the world's coral populations today. One of the solutions to the crisis may lie in human medicine. Prof. Eugene Rosenberg of Tel Aviv University's Department of Molecular⁴ Microbiology and Biotechnology, working in collaboration⁵ with Dr. Ilil Atad of his own laboratory and Prof. Yossi Loya of TAU's Department of Zoology⁶, has developed a treatment for coral infected by Thalassomonas loyana, otherwise known as White Plague disease. This deadly bacterium⁷ infects 9 percent of Favia favus corals on the Eilat coral reef in the Red Sea and readily transmits the disease to nearby healthy corals.

Their treatment uses viruses that infect bacteria by injecting genetic⁸ material into the bacteria, a therapy originally developed to treat bacterial⁹ infections in humans. In this case, the researchers isolated¹⁰ a virus called BA3, one of a category of viruses known as phages（噬菌体）. After laboratory experiments showed that BA3 had the ability to kill off White Plague disease, field experiments in the Gulf¹¹ of Eilat demonstrated that the treatment stopped the progression of the disease in infected corals and prevented the spread of the disease to surrounding healthy corals as well.

These findings were presented at the American Society for Microbiology's general meeting in June.

From human to marine medicine

Treating bacterial infections in corals is no easy task. Because corals don't produce antibodies like humans, they can't be immunized. And pharmaceutical¹² antibiotics¹³ are not a viable¹⁴ option because the treatment releases the drugs into the sea, harming the marine environment.

The researchers applied¹⁵ their treatment to two groups of diseased coral, each surrounded by a circle of healthy corals. In the test group, the researchers injected the virus into the area at a concentration of 1000 per milliliter. The control group did not receive the virus.

After 24 hours, the difference in the outcome was highly significant, says Prof. Rosenberg. In the test group, the infection of the diseased coral ceased its progression, and the disease did not spread to the surrounding healthy corals. In the control group, however, the White Plague disease progressed rapidly in the original infected coral and spread to seven out of ten of the surrounding healthy corals.