By activating¹ a brain circuit that controls compulsive behavior, MIT neuroscientists have shown that they can block a compulsive behavior in mice -- a result that could help researchers develop new treatments for diseases such as obsessive-compulsive disorder² (OCD) and Tourette's syndrome³. About 1 percent of U.S. adults suffer from OCD, and patients usually receive antianxiety drugs or antidepressants, behavioral therapy, or a combination of therapy and medication. For those who do not respond to those treatments, a new alternative is deep brain stimulation⁴, which delivers electrical impulses via a pacemaker implanted in the brain.

 

For this study, the MIT team used optogenetics to control neuron activity with light. This technique is not yet ready for use in human patients, but studies such as this one could help researchers identify brain activity patterns that signal the onset⁵ of compulsive behavior, allowing them to more precisely⁶ time the delivery of deep brain stimulation.

 

"You don't have to stimulate⁷ all the time. You can do it in a very nuanced way," says Ann Graybiel, an Institute Professor at MIT, a member of MIT's McGovern Institute for Brain Research and the senior author of a Science paper describing the study.

 

The paper's lead author is Eric Burguière, a former postdoc in Graybiel's lab who is now at the Brain and Spine⁸ Institute in Paris. Other authors are Patricia Monteiro, a research affiliate⁹ at the McGovern Institute, and Guoping Feng, the James W. and Patricia T. Poitras Professor of Brain and Cognitive¹⁰ Sciences and a member of the McGovern Institute.

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