2型腺病毒能杀死癌细胞与肿瘤细胞
文章来源:未知 文章作者:enread 发布时间:2014-06-25 06:15 字体: [ ]  进入论坛
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A virus not known to cause disease kills triple-negative breast cancer cells and killed tumors grown from these cells in mice, according to Penn State College of Medicine researchers. Understanding how the virus kills cancer may lead to new treatments for breast cancer. Adeno-associated virus type 2 (AAV2) infects humans but is not known to cause sickness. In prior studies, the researchers tested the virus on a variety of breast cancers that represent degrees of aggressiveness and on human papillomavirus-positive cervical(子宫颈的) cancer cells. The virus initiated2 apoptosis(细胞死亡) -- natural cell death -- in cancer cells without affecting healthy cells.
 
"Treatment of breast cancer remains3 difficult because there are multiple signaling pathways that promote tumor1 growth and develop resistance to treatment," said Craig Meyers, Ph.D., Distinguished4 Professor of Microbiology and Immunology.
 
Signaling pathways involve molecules6 in a cell that control cell functions -- such as cell division -- by cooperation. For example, the first molecule5 in the process receives a signal to begin. It then tells another molecule to work, and so on.
 
Treatment of breast cancer differs by patient due to differences in tumors. Some tumors contain protein receptors that are activated7 by the hormones9 estrogen or progesterone. Others respond to another protein called human epidermal10(表皮的) growth factor receptor 2, or HER2. Each of these is treated differently.
 
A triple-negative breast cancer does not have any of these protein receptors and is typically aggressive.
 
"There is an urgent and ongoing11 need for the development of novel therapies which efficiently12 target triple-negative breast cancers," Meyers said.
 
In the current study, the researchers tested AAV2 on a cell-line representative of triple-negative breast cancer. The researchers report their results in Cancer Biology & Therapy.
 
The AAV2 killed 100 percent of the cells in the laboratory by activating13 proteins called caspases, which are essential for the cell's natural death. In addition, consistent with past studies, AAV2-infected cancer cells produced more Ki-67, an immunity14 system activating protein and c-Myc, a protein that helps both to increase cell growth and induce apoptosis. The cancer cell growth slowed by day 17 and all cells were dead by day 21. AAV2 mediated15 cell killing16 of multiple breast cancer cell lines representing both low and high grades of cancer and targeted the cancer cells independent of hormone8 or growth factor classification.
 
The researchers then injected AAV2 into human breast cancer cell line-derived tumors in mice without functioning immune systems. Mice that received AAV2 outlived the untreated mice and did not show signs of being sick, unlike the untreated mice. Tumor sizes decreased in the treated mice, areas of cell death were visible and all AAV2 treated mice survived through the study, a direct contrast to the untreated mice.
 
"These results are significant, since tumor necrosis -- or death -- in response to therapy is also used as the measure of an effective chemotherapeutic(化学疗法的)," Meyers said.
 
Future studies should look at the use of AAV2 body-wide in mice, which would better model what happens in humans, according to Meyers.


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1 tumor fKxzm     
n.(肿)瘤,肿块(英)tumour
参考例句:
  • He was died of a malignant tumor.他死于恶性肿瘤。
  • The surgeons irradiated the tumor.外科医生用X射线照射那个肿瘤。
2 initiated 9cd5622f36ab9090359c3cf3ca4ddda3     
n. 创始人 adj. 新加入的 vt. 开始,创始,启蒙,介绍加入
参考例句:
  • He has not yet been thoroughly initiated into the mysteries of computers. 他对计算机的奥秘尚未入门。
  • The artist initiated the girl into the art world in France. 这个艺术家介绍这个女孩加入巴黎艺术界。
3 remains 1kMzTy     
n.剩余物,残留物;遗体,遗迹
参考例句:
  • He ate the remains of food hungrily.他狼吞虎咽地吃剩余的食物。
  • The remains of the meal were fed to the dog.残羹剩饭喂狗了。
4 distinguished wu9z3v     
adj.卓越的,杰出的,著名的
参考例句:
  • Elephants are distinguished from other animals by their long noses.大象以其长长的鼻子显示出与其他动物的不同。
  • A banquet was given in honor of the distinguished guests.宴会是为了向贵宾们致敬而举行的。
5 molecule Y6Tzn     
n.分子,克分子
参考例句:
  • A molecule of water is made up of two atoms of hygrogen and one atom of oxygen.一个水分子是由P妈?f婘??妈?成的。
  • This gives us the structural formula of the molecule.这种方式给出了分子的结构式。
6 molecules 187c25e49d45ad10b2f266c1fa7a8d49     
分子( molecule的名词复数 )
参考例句:
  • The structure of molecules can be seen under an electron microscope. 分子的结构可在电子显微镜下观察到。
  • Inside the reactor the large molecules are cracked into smaller molecules. 在反应堆里,大分子裂变为小分子。
7 activated c3905c37f4127686d512a7665206852e     
adj. 激活的 动词activate的过去式和过去分词
参考例句:
  • The canister is filled with activated charcoal.蒸气回收罐中充满了活性炭。
8 hormone uyky3     
n.荷尔蒙,激素,内分泌
参考例句:
  • Hormone implants are used as growth boosters.激素植入物被用作生长辅助剂。
  • This hormone interacts closely with other hormones in the body.这种荷尔蒙与体內其他荷尔蒙紧密地相互作用。
9 hormones hormones     
n. 荷尔蒙,激素 名词hormone的复数形式
参考例句:
  • This hormone interacts closely with other hormones in the body. 这种荷尔蒙与体內其他荷尔蒙紧密地相互作用。
  • The adrenals produce a large per cent of a man's sex hormones. 肾上腺分泌人体的大部分性激素。
10 epidermal 5766075fb8cff831ca9f6dcb335ab9bc     
adj. [解][生]表皮的,外皮的
参考例句:
  • Epidermal growth factor is a single-chain peptide with 53 amino-acid residue. 表皮生长因子(epidermal growth factor EGF)是最初从小鼠的下颌下腺提取的一种含有53个氨基酸残基的单链多肽。
  • Telia are dark brown or black, and shine from the intact host epidermal covering. 冬孢子堆呈暗褐色或黑色,覆盖在完整的寄生表皮下显得发亮。
11 ongoing 6RvzT     
adj.进行中的,前进的
参考例句:
  • The problem is ongoing.这个问题尚未解决。
  • The issues raised in the report relate directly to Age Concern's ongoing work in this area.报告中提出的问题与“关心老人”组织在这方面正在做的工作有直接的关系。
12 efficiently ZuTzXQ     
adv.高效率地,有能力地
参考例句:
  • The worker oils the machine to operate it more efficiently.工人给机器上油以使机器运转更有效。
  • Local authorities have to learn to allocate resources efficiently.地方政府必须学会有效地分配资源。
13 activating 948eea612456562bf255d3a9c59c40a3     
活动的,活性的
参考例句:
  • "I didn't say we'd got to stop activating the masses! “我并没说就此不发动! 来自子夜部分
  • Presumably both the very small size and activating influence of fluorine atoms contribute to this exception. 这大概是由于氟原子半径小和活性高这两个原因的影响,氟原子对这种例外做出了贡献。
14 immunity dygyQ     
n.优惠;免除;豁免,豁免权
参考例句:
  • The law gives public schools immunity from taxation.法律免除公立学校的纳税义务。
  • He claims diplomatic immunity to avoid being arrested.他要求外交豁免以便避免被捕。
15 mediated b901b5da5d438661bcf0228b9947a320     
调停,调解,斡旋( mediate的过去式和过去分词 ); 居间促成; 影响…的发生; 使…可能发生
参考例句:
  • He mediated in the quarrel between the two boys. 他调解两个孩子之间的争吵。
  • The government mediated between the workers and the employers. 政府在工人与雇主间搞调和。
16 killing kpBziQ     
n.巨额利润;突然赚大钱,发大财
参考例句:
  • Investors are set to make a killing from the sell-off.投资者准备清仓以便大赚一笔。
  • Last week my brother made a killing on Wall Street.上个周我兄弟在华尔街赚了一大笔。
TAG标签: cells cancer virus
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