Many genetic¹ mutations in visual pigments², spread over millions of years, were required for humans to evolve from a primitive³ mammal with a dim, shadowy view of the world into a greater ape able to see all the colors in a rainbow. Now, after more than two decades of painstaking⁴ research, scientists have finished a detailed⁵ and complete picture of the evolution of human color vision. PLOS Genetics published the final pieces of this picture: The process for how humans switched from ultraviolet (UV) vision to violet vision, or the ability to see blue light.

 

"We have now traced all of the evolutionary⁶ pathways, going back 90 million years, that led to human color vision," says lead author Shozo Yokoyama, a biologist at Emory University. "We've clarified these molecular⁷ pathways at the chemical level, the genetic level and the functional⁸ level."

 

Co-authors of the PLOS Genetics paper include Emory biologists Jinyi Xing, Yang Liu and Davide Faggionato; Syracuse University biologist William Starmer; and Ahmet Altun, a chemist and former post-doc at Emory who is now at Fatih University in Istanbul, Turkey.

 

Yokoyama and various collaborators over the years have teased out secrets of the adaptive evolution of vision in humans and other vertebrates by studying ancestral molecules⁹. The lengthy¹⁰ process involves first estimating and synthesizing ancestral proteins and pigments of a species, then conducting experiments on them. The technique combines microbiology with theoretical computation, biophysics, quantum chemistry and genetic engineering.

 

Five classes of opsin genes¹¹ encode visual pigments for dim-light and color vision. Bits and pieces of the opsin genes change and vision adapts as the environment of a species changes.

 

Around 90 million years ago, our primitive mammalian ancestors were nocturnal and had UV-sensitive and red-sensitive color, giving them a bi-chromatic view of the world. By around 30 million years ago, our ancestors had evolved four classes of opsin genes, giving them the ability to see the full-color spectrum¹² of visible light, except for UV.

 

"Gorillas¹⁴ and chimpanzees have human color vision," Yokoyama says. "Or perhaps we should say that humans have gorilla¹³ and chimpanzee vision."

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