New research suggests that people who are exposed to low levels of sunlight coupled with a history of having a common virus known as mononucleosis（单核细胞增多症） may be at greater odds¹ of developing multiple sclerosis (MS多发性硬化) than those without the virus. The research is published in the April 19, 2011, print issue of Neurology®, the medical journal of the American Academy of Neurology. "MS is more common at higher latitudes², farther away from the equator," said George C. Ebers, MD, with the University of Oxford³ in the United Kingdom and a member of the American Academy of Neurology. "Since the disease has been linked to environmental factors such as low levels of sun exposure and a history of infectious mononucleosis, we wanted to see whether the two together would help explain the variance⁴ in the disease across the United Kingdom."

Infectious mononucleosis is a disease caused by the Epstein-Barr virus, which is a Herpes virus that is extremely common but causes no symptoms in most people. However, when a person contracts the virus as a teenager or adult, it often leads to infectious mononucleosis. The body makes vitamin D when exposed to ultraviolet B (UVB) light.

For the study, researchers looked at all hospital admissions to National Health Service hospitals in England over seven years. Specifically, they identified 56,681 cases of multiple sclerosis and 14,621 cases of infectious mononucleosis. Scientists also looked at NASA data on ultraviolet intensity⁵ in England.

The study found that adding the effects of sunlight exposure and mononucleosis together explained 72 percent of the variance in the occurrence of MS across the United Kingdom. Sunlight exposure alone accounted for 61 percent of the variance.

"It's possible that vitamin D deficiency may lead to an abnormal response to the Epstein-Barr virus," Ebers said.

He noted⁶ that low sunlight exposure in the spring was most strongly associated with MS risk. "Lower levels of UVB in the spring season correspond with peak risk of MS by birth month. More research should be done on whether increasing UVB exposure or using vitamin D supplements and possible treatments or vaccines⁷ for the Epstein-Barr virus could lead to fewer cases of MS."